prikaz prve stranice dokumenta Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population
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Scientific paper - Original scientific paper
Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population
Clinical Rheumatology, 34 (2015), 12; 2079-2086. https://doi.org/10.1007/s10067-015-2952-8
Perica, Marija; Vidović, Mandica; Lamot, Lovro; Tambić Bukovac, Lana; Kapitanović, Sanja; Perić, Magdalena; Barbić, Jerko; Harjaček, Miroslav

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Perica, M., Vidović, M., Lamot, L., Tambić Bukovac, L., Kapitanović, S., Perić, M. ... Harjaček, M. (2015). Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population. Clinical Rheumatology, 34. (12), 2079-2086. doi: 10.1007/s10067-015-2952-8

Perica, Marija, et al. "Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population." Clinical Rheumatology, vol. 34, no. 12, 2015, pp. 2079-2086. https://doi.org/10.1007/s10067-015-2952-8

Perica, Marija, Mandica Vidović, Lovro Lamot, Lana Tambić Bukovac, Sanja Kapitanović, Magdalena Perić, Jerko Barbić and Miroslav Harjaček. "Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population." Clinical Rheumatology 34, no. 12 (2015): 2079-2086. https://doi.org/10.1007/s10067-015-2952-8

Perica, M., et al. (2015) 'Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population', Clinical Rheumatology, 34(12), pp. 2079-2086. doi: 10.1007/s10067-015-2952-8

Perica M, Vidović M, Lamot L, Tambić Bukovac L, Kapitanović S, Perić M, and sur.. Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population. Clinical Rheumatology [Internet]. 2015 [cited 2024 December 07];34(12):2079-2086. doi: 10.1007/s10067-015-2952-8

M. Perica, et al., "Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population", Clinical Rheumatology, vol. 34, no. 12, pp. 2079-2086, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:153096. [Accessed: 07 December 2024]

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Metadata
Title (english)Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population
AuthorMarija Perica
AuthorMandica Vidović
AuthorLovro Lamot
MBZ: 301805
AuthorLana Tambić Bukovac
MBZ: 192211
AuthorSanja Kapitanović
MBZ: 200570
AuthorMagdalena Perić
MBZ: 339363
AuthorJerko Barbić
MBZ: 258420
AuthorMiroslav Harjaček
MBZ: 240313
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		SOCIAL SCIENCES
Demography
General Demographics
Abstract (english)
Single nucleotide polymorphisms (SNP) of toll-like and NOD-like receptors have been associated with altered receptor activity and modified production of proinflammatory cytokines leading to a number of diseases. Our aim was to determine whether SNP of TLR2 (Arg753Gln), TLR4 (Asp299Gly, Thr399Ile), and NLRP3 (Q705K) influence susceptibility to juvenile spondyloarthrtis (jSpA) and juvenile idiopathic arthritis (JIA). After the DNA extraction, 26 patients with jSpA, 11 with oligoarticular, polyarticular, or systemic JIA, and 40 healthy controls were genotyped for Arg753Gln, Asp299Gly, Thr399Ile, and Q705K SNP using real-time PCR-SNP analysis. Statistically significant difference in genotype frequency for Thr399Ile SNP of TLR4 was observed in the jSpA (χ2 = 6.705, p = 0.035) and not in the JIA group (χ2 = 3005, p = 0.223). Regarding Asp299Gly SNP, no significant difference in genotype frequency was found; however, allele frequency was significant in both jSpA and JIA patients. No significant difference in genotype or allele frequency was observed for Arg735Gln and Q705K SNP. The399Ile polymorphism of TLR4 may be responsible for altered immune response to microbial infection in variant carriers and represent a mechanism of triggering overproduction of proinflammatory cytokines and long-term inflammation in jSpA. SNP of TLR2, NLRP3, and TLR4 (Asp299Gly) were not associated with jSpA or JIA.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical Rheumatology
Numberingvol. 34, no. 12, pp. 2079-2086
p-ISSN0770-3198
e-ISSN1434-9949
DOIhttps://doi.org/10.1007/s10067-015-2952-8
URN:NBNurn:nbn:hr:239:153096
Publication2015
Document URLhttps://link.springer.com/article/10.1007/s10067-015-3083-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-10-31 10:45:24