prikaz prve stranice dokumenta Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology
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Scientific paper - review paper
Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology
Asian Journal of Urology, 3 (2016), 4; 240-253. https://doi.org/10.1016/j.ajur.2016.08.005
Wang, Ruoxiang; Chu, Chia-Yi; Mrđenović, Stefan; Annamalai, Alagappan A.; Hendifar, Andrew E.; Nissen, Nicholas N.; Tomlinson, James S.; Lewis, Michael; Palanisamy, Nallasivam; Tseng, Hsian-Rong; Posadas, Edwin M.; Stephen J., Pandol; Zhau, Haiyen E.; Chung, Leland W.K.

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Wang, R., Chu, C. Y., Mrđenović, S., Annamalai, A. A., Hendifar, A. E., Nissen, N. N. ... Chung, L. W. (2016). Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology. Asian Journal of Urology, 3. (4), 240-253. doi: 10.1016/j.ajur.2016.08.005

Wang, Ruoxiang, et al. "Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology." Asian Journal of Urology, vol. 3, no. 4, 2016, pp. 240-253. https://doi.org/10.1016/j.ajur.2016.08.005

Wang, Ruoxiang, Chia Yi Chu, Stefan Mrđenović, Alagappan A. Annamalai, Andrew E. Hendifar, Nicholas N. Nissen, James S. Tomlinson, et al. "Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology." Asian Journal of Urology 3, no. 4 (2016): 240-253. https://doi.org/10.1016/j.ajur.2016.08.005

Wang, R., et al. (2016) 'Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology', Asian Journal of Urology, 3(4), pp. 240-253. doi: 10.1016/j.ajur.2016.08.005

Wang R, Chu CY, Mrđenović S, Annamalai AA, Hendifar AE, Nissen NN, and sur.. Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology. Asian Journal of Urology [Internet]. 2016 [cited 2024 December 07];3(4):240-253. doi: 10.1016/j.ajur.2016.08.005

R. Wang, et al., "Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology", Asian Journal of Urology, vol. 3, no. 4, pp. 240-253, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:568078. [Accessed: 07 December 2024]

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Metadata
Title (english)Cultured Circulating Tumor Cells and Their Derived Xenografts for Personalized Oncology
AuthorRuoxiang Wang
AuthorChia-Yi Chu
AuthorStefan Mrđenović
MBZ: 103524
AuthorAlagappan A. Annamalai
AuthorAndrew E. Hendifar
AuthorNicholas N. Nissen
AuthorJames S. Tomlinson
AuthorMichael Lewis
AuthorNallasivam Palanisamy
AuthorHsian-Rong Tseng
AuthorEdwin M. Posadas
AuthorPandol Stephen J.
AuthorHaiyen E. Zhau
AuthorLeland W.K. Chung
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Recent cancer research has demonstrated the existence of circulating tumor cells (CTCs) in cancer patient's blood. Once identified, CTC biomarkers will be invaluable tools for clinical diagnosis, prognosis and treatment. In this review, we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample, to derive enough CTCs for accurate and reproducible characterization of the biophysical, biochemical, gene expressional and behavioral properties of the harvested cells. Because of tumor cell heterogeneity, it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer metastasis. By analyzing critical steps and technical issues in ex vivo CTC culture, we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells, relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells.
Keywords (english)
Languageenglish
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAsian Journal of Urology
Numberingvol. 3, no. 4, pp. 240-253
p-ISSN2214-3882
e-ISSN2214-3890
DOIhttps://doi.org/10.1016/j.ajur.2016.08.005
URN:NBNurn:nbn:hr:239:568078
Publication2016
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730836/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-11-08 11:56:06