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Scientific paper - Original scientific paper
Kinetics of Changes in Serum Concentrations of Procalcitonin, Interleukin-6, and C- Reactive Protein after Elective Abdominal Surgery. Can it Be Used to Detect Postoperative Complications?
Collegium antropologicum, 37 (2013), 1; 195-203. urn:nbn:hr:239:420822
Barbić, Jerko; Ivić, Dubravka; Alkhamis, Tamara; Drenjančević, Domagoj; Ivić, Josip; Haršanji-Drenjančević, Ivana; Turina, Ivana; Včev, Aleksandar

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Barbić, J., Ivić, D., Alkhamis, T., Drenjančević, D., Ivić, J., Haršanji Drenjančević, I. ... Včev, A. (2013). Kinetics of Changes in Serum Concentrations of Procalcitonin, Interleukin-6, and C- Reactive Protein after Elective Abdominal Surgery. Can it Be Used to Detect Postoperative Complications?. Collegium antropologicum, 37. (1), 195-203. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:420822

Barbić, Jerko, et al. "Kinetics of Changes in Serum Concentrations of Procalcitonin, Interleukin-6, and C- Reactive Protein after Elective Abdominal Surgery. Can it Be Used to Detect Postoperative Complications?." Collegium antropologicum, vol. 37, no. 1, 2013, pp. 195-203. https://urn.nsk.hr/urn:nbn:hr:239:420822

Barbić, Jerko, Dubravka Ivić, Tamara Alkhamis, Domagoj Drenjančević, Josip Ivić, Ivana Haršanji Drenjančević, Ivana Turina and Aleksandar Včev. "Kinetics of Changes in Serum Concentrations of Procalcitonin, Interleukin-6, and C- Reactive Protein after Elective Abdominal Surgery. Can it Be Used to Detect Postoperative Complications?." Collegium antropologicum 37, no. 1 (2013): 195-203. https://urn.nsk.hr/urn:nbn:hr:239:420822

Barbić, J., et al. (2013) 'Kinetics of Changes in Serum Concentrations of Procalcitonin, Interleukin-6, and C- Reactive Protein after Elective Abdominal Surgery. Can it Be Used to Detect Postoperative Complications?', Collegium antropologicum, 37(1), pp. 195-203. Available at: https://urn.nsk.hr/urn:nbn:hr:239:420822 (Accessed 08 June 2023)

Barbić J, Ivić D, Alkhamis T, Drenjančević D, Ivić J, Haršanji Drenjančević I, and sur.. Kinetics of Changes in Serum Concentrations of Procalcitonin, Interleukin-6, and C- Reactive Protein after Elective Abdominal Surgery. Can it Be Used to Detect Postoperative Complications?. Collegium antropologicum [Internet]. 2013 [cited 2023 June 08];37(1):195-203. Available at: https://urn.nsk.hr/urn:nbn:hr:239:420822

J. Barbić, et al., "Kinetics of Changes in Serum Concentrations of Procalcitonin, Interleukin-6, and C- Reactive Protein after Elective Abdominal Surgery. Can it Be Used to Detect Postoperative Complications?", Collegium antropologicum, vol. 37, no. 1, pp. 195-203, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:420822. [Accessed: 08 June 2023]

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Title (english)Kinetics of Changes in Serum Concentrations of Procalcitonin, Interleukin-6, and C- Reactive Protein after Elective Abdominal Surgery. Can it Be Used to Detect Postoperative Complications?
AuthorJerko Barbić
MBZ: 258420
AuthorDubravka Ivić
MBZ: 204122
AuthorTamara Alkhamis
MBZ: 302944
AuthorDomagoj Drenjančević
MBZ: 297300
AuthorJosip Ivić
MBZ: 236546
AuthorIvana Haršanji-Drenjančević
MBZ: 363764
AuthorIvana Turina
AuthorAleksandar Včev
MBZ: 141721
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
(Department of Anesthesiology, Resuscitation, Intensive Care Medicine and Pain Management)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Postoperative increase in inflammation biologic markers is associated with a nonspecific inflammatory response to a surgical injury. We investigated the kinetics of changes in serum concentrations of procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) after abdominal surgeries and we focused on the behaviour of those markers in the case of development of the systemic inflammatory response syndrome (SIRS). In the single centre we conducted a prospective observational study and we included patients admitted to the ICU after elective abdominal surgery. A total of 41 patients were included and 8 (19.5%) of them had clinical and laboratory signs of SIRS. Sepsis was confirmed in one of the patients, a 72-year old patient operated due to having an abdominal aortic aneurysm. Plasma concentrations of PCT, CRP and IL-6 were measured in all the patients before surgery and at the postoperative day 1 (POD1), postoperative day 2 (POD2) and postoperative day 3 (POD3). Systemic release of PCT, CRP and IL-6 was present in all the measured time points after the abdominal surgery. Median concentrations of IL-6 (100.4 pg/mL) and PCT (1, 17 pg/mL) production were measured highest at POD1 and the median of CRP (147 mg/L) was measured at highest POD2. A larger increase of all three measured markers was found in patients with SIRS compared to those without. IL-6 at POD1 and POD 2 was a good predictor of SIRS (areas under curves were 0.71 and 0.765, respectively), showing the highest accuracy among investigated markers at those time points. CRP at POD3 was a good predictor of SIRS (AUC was 0.76). A cut-off of 95 mg/mL in the level of CRP at POD3 yielded a sensitivity of 87.5% and specificity of 66.7% in detecting SIRS. IL-6 and CRP were the best in detecting postoperative SIRS after abdominal surgery with the highest area under ROC curve. This study is showing that PCT is not a good marker of SIRS caused only by surgical injury without sepsis.
Abstract (croatian)
Postoperativno povećanje serumskih koncentracija upalnih bioloških markera povezuje se s nespecifičnim upalnim odgovorom na kiruršku ozljedu. U na{em istraživanju proučavali smo dinamiku promjena serumskih koncentracija prokalcitonina (PCT), C-reaktivnog proteina (CRP) i interleukina-6 (IL-6) nakon elektivnih abdominalnih operacija s naglaskom na ponašanje ovih markera u slučaju razvoja sindroma sistemskog upalnog odgovora (SIRS, od engl. Systemic inflammatory response syndrome). Prospektivna opservacijska studija provedena u našem kliničkom bolničkom centru uključivala je pacijente koji su nakon elektivnih abdominalnih operacija bili primljeni na jedinicu intenzivnog liječenja. Ukupno su razmotrena 41 bolesnika, od kojih je 8 (19,5%) pokazivalo znakove SIRS-a. Sepsa je utvrđena u samo jednog bolesnika, 72-godišnjaka hospitaliziranog nakon operacije abdominalne aortalne aneurizme. Serumske koncentracije PCT, CRP i IL-6 mjerene su u svih ispitanika prije operacije, te u tri navrata nakon operacije, i to tijekom prvog (POD1), drugog (POD2) i tre}eg (POD3) postoperativnog dana. Tijekom svih mjerenja koja su uslijedila nakon abdominalne operacije zabilježeno je oslobađanje spomenutih markera u serum. Najveći medijani sekrecije za IL-6 (100,4 pg/mL) te za PCT (1,17pg/mL) zabilježeni su tijekom POD1 mjerenja, dok je za CRP najveći medijan izmjeren tijekom POD2 mjerenja (147 mg/mL). U pacijenata sa SIRS-om utvrđeno je veće povećanje u koncentraciji sva tri markera nego u onih bez sindroma sustavnog upalnog odgovora. IL-6 se tijekom POD1 i POD2 pokazao kao dobar predskazatelj mogućeg razvoja SIRS-a (područja ispod ROC-krivulje (AUC, prema engl. Area under curve) iznosila su 0,71 za POD1 te 0,765 za POD2), pokazujući najveću točnost među trima ispitanim markerima tijekom prva dva postoperativna dana. Mjerenje razina CRP-a tijekom POD3 također se pokazalo prediktivnima s obzirom na razvoj SIRS-a (AUC je iznosio 0,76). Prag od 95mg/ml za razine CRP-a tijekom POD3 polučio je osjetljivost od 87,5% te specifičnost od 66,7% pri otkrivanju SIRS-a. Razine IL-6 i CRP tijekom navedenih mjerenja pokazale su se kao dobri predskazatelji razvoja SIRS-a, za razliku od PCT-a, koji se tijekom ove studije nije pokazao kao dobar marker za otkrivanje SIRS-a uzrokovanog isključivo kirurškom ozljedom
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 37, no. 1, pp. 195-203
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:420822
Publication2013
Document URLhttps://hrcak.srce.hr/99558
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-01-31 12:46:39