prikaz prve stranice dokumenta Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure
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Scientific paper - Original scientific paper
Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure
Acta clinica Croatica, 56 (2017), 4; 733-741. https://doi.org/10.20471/acc.2017.56.04.22
Makarović, Sandra; Makarović, Zorin; Bilić-Ćurčić, Ines; Milas-Ahić, Jasminka; Mihaljević, Ivan; Franceschi, Maja; Jukić, Tomislav

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Makarović, S., Makarović, Z., Bilić Ćurčić, I., Milas Ahić, J., Mihaljević, I., Franceschi, M. & Jukić, T. (2017). Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure. Acta clinica Croatica, 56. (4), 733-741. doi: 10.20471/acc.2017.56.04.22

Makarović, Sandra, et al. "Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure." Acta clinica Croatica, vol. 56, no. 4, 2017, pp. 733-741. https://doi.org/10.20471/acc.2017.56.04.22

Makarović, Sandra, Zorin Makarović, Ines Bilić Ćurčić, Jasminka Milas Ahić, Ivan Mihaljević, Maja Franceschi and Tomislav Jukić. "Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure." Acta clinica Croatica 56, no. 4 (2017): 733-741. https://doi.org/10.20471/acc.2017.56.04.22

Makarović, S., et al. (2017) 'Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure', Acta clinica Croatica, 56(4), pp. 733-741. doi: 10.20471/acc.2017.56.04.22

Makarović S, Makarović Z, Bilić Ćurčić I, Milas Ahić J, Mihaljević I, Franceschi M, and sur.. Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure. Acta clinica Croatica [Internet]. 2017 [cited 2023 May 28];56(4):733-741. doi: 10.20471/acc.2017.56.04.22

S. Makarović, et al., "Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure", Acta clinica Croatica, vol. 56, no. 4, pp. 733-741, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:386712. [Accessed: 28 May 2023]

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Title (english)Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure
Title (croatian)Serumska vrijednost osteoprotegerina u bolesnika s kalcificirajućom aortnom stenozom u ovisnosti o zatajenju srca
AuthorSandra Makarović
MBZ: 364616
AuthorZorin Makarović
MBZ: 370863
AuthorInes Bilić-Ćurčić
MBZ: 268184
AuthorJasminka Milas-Ahić
MBZ: 288280
AuthorIvan Mihaljević
MBZ: 273143
AuthorMaja Franceschi
MBZ: 79750
AuthorTomislav Jukić
Author's institution(Clinical hospital center Osijek)
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The aim of the study was to assess the role of serum osteoprotegerin (OPG) as a biomarker in patients with aortic valve stenosis (AS) in relation to heart failure and symptomatic status. This was a case control study, which included 51 patients with AS and 39 control subjects. At the time of study enrolment, detailed medical history was obtained and all subjects underwent physical examination, chest x-ray and echocardiography. OPG levels were measured in all subjects, and serum N-terminal of the pro b-type natriuretic peptide (NT pro BNP) levels were determined in patients with AS. Serum OPG levels were elevated in patients with AS compared to control subjects (p=0.001). Pa-tients with heart failure due to AS had elevated serum OPG levels in comparison to patients without heart failure (p=0.001). A significant correlation between OPG and symptomatic status was observed in all patients with AS (p<0.001), however, it was not the case in patients without heart failure (p=0.425). There was a positive correlation between OPG and NT pro BNP concentrations with objective signs of heart failure on chest x-ray (p<0.001). Negative correlation of OPG concentrations with aortic valve area was present (p<0.040), as well as with left ventricular ejection fraction (p<0.001). Serum OPG could be a valuable biomarker in the evaluation of severity of calcified AS and serve as an additional indicator besides clinical presentation and echocardiography in the assessment of surgical treatment or aortic valve replacement.
Abstract (croatian)
Cilj ove studije bio je ocijeniti ulogu osteoprotegerina (OPG) kao biljega u bolesnika sa stenozom aortnog srčanog za-liska u odnosu na prisutne simptome kao i stupanj srčanog zatajenja. U studiju je bio uključen 51 bolesnik s aortnom steno-zom (AS) i 39 kontrolnih ispitanika. Prije uključenja u studiju uzeta je detaljna anamneza, učinjen je fizikalni pregled, ren-tgenska snimka srca i pluća te ehokardiografija. OPG je određen u svih ispitanika, a N-terminalni nastavak pro b-tipa natriu-retskog peptida (NT pro BNP) bio je određen u bolesnika s AS. OPG je bio povišen u bolesnika s AS u odnosu na kontrolne ispitanike (p=0,001). Bolesnici sa srčanim zatajenjem zbog AS imali su povišene razine OPG-a u odnosu na bolesnike bez srčanog zatajenja (p=0,001). Značajna korelacija između OPG-a i simptomatskog statusa bila je zapažena u svih bolesnika s AS (p<0,001), ali to nije bio slučaj u bolesnika bez srčanog zatajenja (p=0.425). Zabilježena je i pozitivna korelacija između koncentracije OPG-a i NT pro BNP-a s objektivnim znakovima srčanog zatajenja na rentgenskoj snimci srca i pluća (p<0,001). Također je opažena negativna korelacija OPG-a i areje aortnog zaliska (p<0,040) te istisne frakcije lijeve klijetke (p<0,001). OPG bi mogao predstavljati vrijedan biljeg u procjeni težine kalcificirane AS te bi mogao poslužiti kao dodatni indikator prilikom odlučivanja o kirurškom liječenju ili zamjeni aortnog zaliska, naravno, uz kliničku prezentaciju i ehokardiografiju.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 56, no. 4, pp. 733-741
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2017.56.04.22
URN:NBNurn:nbn:hr:239:386712
Publication2017
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=288151
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-07-11 08:40:44