prikaz prve stranice dokumenta Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians
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Scientific paper - Original scientific paper
Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians
Collegium antropologicum, 38 (2014), 1; 141-146. urn:nbn:hr:239:491614
Mandić, Sanja; Horvat, Vesna; Marczi, Saška; Lukić, Ivana; Galić, Josip

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Mandić, S., Horvat, V., Marczi, S., Lukić, I. & Galić, J. (2014). Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians. Collegium antropologicum, 38. (1), 141-146. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:491614

Mandić, Sanja, et al. "Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians." Collegium antropologicum, vol. 38, no. 1, 2014, pp. 141-146. https://urn.nsk.hr/urn:nbn:hr:239:491614

Mandić, Sanja, Vesna Horvat, Saška Marczi, Ivana Lukić and Josip Galić. "Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians." Collegium antropologicum 38, no. 1 (2014): 141-146. https://urn.nsk.hr/urn:nbn:hr:239:491614

Mandić, S., et al. (2014) 'Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians', Collegium antropologicum, 38(1), pp. 141-146. Available at: https://urn.nsk.hr/urn:nbn:hr:239:491614 (Accessed 16 November 2024)

Mandić S, Horvat V, Marczi S, Lukić I, Galić J. Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians. Collegium antropologicum [Internet]. 2014 [cited 2024 November 16];38(1):141-146. Available at: https://urn.nsk.hr/urn:nbn:hr:239:491614

S. Mandić, V. Horvat, S. Marczi, I. Lukić and J. Galić, "Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians", Collegium antropologicum, vol. 38, no. 1, pp. 141-146, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:491614. [Accessed: 16 November 2024]

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Metadata
Title (english)Association Study of Cytochrome P450 1A1*2A Polymorphism with Prostate Cancer Risk and Aggressiveness in Croatians
Title (croatian)Ispitivanje povezanosti polimorfizma citokroma p450 1a1*2a s rizikom od karcinoma prostate i agresivnošću u hrvatskoj populaciji
AuthorSanja Mandić
MBZ: 349013
AuthorVesna Horvat
MBZ: 349024
AuthorSaška Marczi
MBZ: 254853
AuthorIvana Lukić
MBZ: 358140
AuthorJosip Galić
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Cytochrome P450 1A1 (CYP1A1) is an enzyme participating in the bioactivation of various endogenous and environmental reactive compounds that can bind to DNA and thus induce cancerogenesis. Gene encoding the enzyme is expressed in the prostate tissue and is polymorphic. CYP1A1*2A gene polymorphism is associated with elevated enzyme activity and/or inducibility which can lead to accumulation of genotoxic compounds and consequently to cancerogenesis. We examined the association of this polymorphism with prostate cancer (PCa) risk and aggressiveness. The case-control study consisted of 120 PCa patients and 120 benign prostatic hyperplasia (BPH) controls, in Croatian population. Regarding aggressiveness, PCa patients were grouped according to the Gleason score (GS), tumor stage (T) and existence of distant metastasis (M). The polymorphism was analyzed using real-time polymerase chain reaction (PCR). We did not observe association of mutated allele with PCa risk, neither with PCa aggressiveness. Furthermore, frequency of polymorphic genotype was slightly higher in BPH group (16.6% vs. 14.2%, respectively) and also in less aggressive form of PCa (20.4% vs. 9.6% for GS<7; 15.6% vs. 9.1% for T<3; 16.7% vs. 10.0% for no distant metastasis). Comparing our findings with other published results, we can assume that the ethnicity influence the genotype distribution and thus may affect the etiology of PCa, even possibly in the way to cause an opposite effect among different ethnic groups. Given the small number of participants, results should be validated on the larger sample size.
Abstract (croatian)
Citokrom P450 1A1 (CYP1A1) je enzim koji sudjeluje u bioaktivaciji raznih endogenih i egzogenih reaktivnih spojeva koji se mogu vezati na DNA i tako izazvati karcinogenezu. Gen koji kodira taj enzim je eksprimiran u tkivu prostate i polimorfan. CYP1A1*2A genski polimorfizam je povezan s povišenom aktivnošću i/ili inducibilnoću enzima što može dovesti do nakupljanja genotoksičnih spojeva i posljedično do karcinogeneze. Ispitali smo povezanost tog polimorfizma s rizikom od karcinoma prostate i agresivnošću. Studija ispitivanja parova sastojala se od 120 pacijenata s karcinomom prostate (PCa) i 120 kontrola s benignom hiperplazijom prostate (BPH), stanovni{tva Hrvatske. Obzirom na agresivnost, PCa pacijenti su grupirani prema Gleason zbroju (GS), stadiju tumora (T) i postojanju udaljenih metastaza (M). Polimorfizam je analiziran pomoću lanžane reakcije polimeraze (PCR). Nismo uočili povezanost između mutiranog alela i rizika od PCa, niti s bilo kojim ispitivanim parametrom agresivnosti. Štoviše, frekvencija polimorfnog genotipa bila je viša u skupini BPH (16,6% naspram 14,2%) i u manje agresivnom obliku PCa (20,4% naspram 9,6% za GS<7; 15,6% naspram 9,1% za T<3; 16,7% naspram 10,0% za M0). Uspoređujući naše rezultate s drugim objavljenim rezultatima možemo pretpostaviti da etni~ka pripadnost mo`e utjecati na distribuciju i tako utjecati na etiologiju PCa, čak možda i na način da izazove suprotan učinak kod različitih etničkih skupina. Obzirom na mali broj ispitanika, rezultate bi trebalo potvrditi na većem uzorku.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 38, no. 1, pp. 141-146
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:491614
Publication2014
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=178794
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-15 10:27:39