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Scientific paper - Original scientific paper
Measurable and Unmeasurable Features of Ultrasound Lymph Node Images in Detection of Malignant Infiltration
Acta clinica Croatica, 56 (2017), 3; 415-424. urn:nbn:hr:239:416614
Rotim, Tatjana; Kristek, Branka; Turk, Tajana; Kretić, Domagoj; Perić, Marija; Pušeljić, Ivo; Pandurović, Tijana; Štefanić, Mario

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Rotim, T., Kristek, B., Turk, T., Kretić, D., Perić, M., Pušeljić, I. ... Štefanić, M. (2017). Measurable and Unmeasurable Features of Ultrasound Lymph Node Images in Detection of Malignant Infiltration. Acta clinica Croatica, 56. (3), 415-424. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:416614

Rotim, Tatjana, et al. "Measurable and Unmeasurable Features of Ultrasound Lymph Node Images in Detection of Malignant Infiltration." Acta clinica Croatica, vol. 56, no. 3, 2017, pp. 415-424. https://urn.nsk.hr/urn:nbn:hr:239:416614

Rotim, Tatjana, Branka Kristek, Tajana Turk, Domagoj Kretić, Marija Perić, Ivo Pušeljić, Tijana Pandurović and Mario Štefanić. "Measurable and Unmeasurable Features of Ultrasound Lymph Node Images in Detection of Malignant Infiltration." Acta clinica Croatica 56, no. 3 (2017): 415-424. https://urn.nsk.hr/urn:nbn:hr:239:416614

Rotim, T., et al. (2017) 'Measurable and Unmeasurable Features of Ultrasound Lymph Node Images in Detection of Malignant Infiltration', Acta clinica Croatica, 56(3), pp. 415-424. Available at: https://urn.nsk.hr/urn:nbn:hr:239:416614 (Accessed 07 December 2024)

Rotim T, Kristek B, Turk T, Kretić D, Perić M, Pušeljić I, and sur.. Measurable and Unmeasurable Features of Ultrasound Lymph Node Images in Detection of Malignant Infiltration. Acta clinica Croatica [Internet]. 2017 [cited 2024 December 07];56(3):415-424. Available at: https://urn.nsk.hr/urn:nbn:hr:239:416614

T. Rotim, et al., "Measurable and Unmeasurable Features of Ultrasound Lymph Node Images in Detection of Malignant Infiltration", Acta clinica Croatica, vol. 56, no. 3, pp. 415-424, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:416614. [Accessed: 07 December 2024]

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Metadata
Title (english)Measurable and Unmeasurable Features of Ultrasound Lymph Node Images in Detection of Malignant Infiltration
Title (croatian)Vrijednost mjerljivih i nemjerljivih značajka ultrazvučnog prikaza limfnih čvorova u otkrivanju zloćudnog zauzeća
AuthorTatjana Rotim
MBZ: 368784
AuthorBranka Kristek
MBZ: 202853
AuthorTajana Turk
MBZ: 368795
AuthorDomagoj Kretić
MBZ: 370826
AuthorMarija Perić
AuthorIvo Pušeljić
AuthorTijana Pandurović
AuthorMario Štefanić
MBZ: 288502
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Cytology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
The aim of the study was to assess diagnostic value and utility of selected morphological features in predicting lymph node (LN) malignancy using B-mode, Doppler ultrasonography and multivariate settings in a tertiary radiological referral center. The study included 123 patients having undergone ultrasound-guided fine-needle aspiration and cytologic analysis (FNAC) of cervical, axillary and inguinal LNs. Each LN was characterized by long/L and short/T-axis, shape, margins, echogenicity, cortical thickness, vascularization, and examiner’s subjective impression. Within the limitations of FNAC, altered shape and vascularization had relatively high specificity and positive predictive value (>80%), whereas subjective impression had high sensitivity and negative predictive value (100%) for malignancy. The cut-off levels for different features of LN by ROC analysis were as follows: long-axis 23 mm, short-axis 11 mm, L/T ratio 2.19, and maximal cortical thickness 5.1 mm. On multivariate analysis (adaptive regression splines, n=108), the addition of long-axis, L/T ratio, age and sex considerably improved diagnostic accuracy (88%), sensitivity (margins + vascularization) and specificity (subjective impression) of the diagnostic model. The combination of morphological and demographic features could improve diagnostic accuracy, usually with a trade-off between the sensitivity and specificity of the predictive model. The performance may depend on the level of expertise and institutional settings.
Abstract (croatian)
Cilj istraživanja bio je odrediti dijagnostičku vrijednost i korisnost odabranih morfoloških značajka u predviđanju malignosti limfnog čvora (LČ) upotrebom B-moda, Dopplerova ultrazvuka i multivarijatnih postavka u tercijarnom radiološkom referentnom centru. U 123 bolesnika je učinjena ultrazvučno vođena aspiracijska punkcija i citološka analiza LČ vrata, pazuha i prepona. Svaki LČ je opisan uzdužnim/L i poprečnim/T promjerom, oblikom, rubom, ehogenošću, debljinom kore, vaskularizacijom i subjektivnim dojmom pregledavatelja. Unutar ograničenja citološke analize, izmijenjen oblik i vaskularizacija su imali visoku specifičnost i pozitivnu prediktivnu vrijednost (>80%), dok je subjektivni dojam imao visoku osjetljivost i negativnu prediktivnu vrijednost (100%) za malignost. Optimalne granične vrijednosti za različite značajke LČ dobivene analizom ROC su bile 23 mm za uzdužni promjer, 11 mm za poprečni promjer, 2,19 za omjer L/T i 5,1 mm za maksimalnu debljinu korteksa. U multivarijatnoj analizi (adaptive regression splines, n=108) dodatak uzdužnog promjera, omjera L/T, dobi i spola semikvalitativnim obilježjima LČ značajno je povećao dijagnostičku točnost (88%), osjetljivost (rubovi + vaskularizacija, 87%) i specifičnost (subjektivni dojam, 83%) konačnog dijagnostičkog modela. U zaključku, kombinacija morfoloških i demografskih značajka može poboljšati dijagnostičku točnost, obično uz kompromis između osjetljivosti i specifičnosti prediktivnog modela. Učinkovitost može ovisiti o razini stručnosti i institucionalnim postavkama.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa clinica Croatica
Numberingvol. 56, no. 3, pp. 415-424
p-ISSN0353-9466
e-ISSN1333-9451
URN:NBNurn:nbn:hr:239:416614
Publication2017
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=282180
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-05-21 08:41:37