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Professional paper - Review paper
The Effects of Physical Activity on Chronic Subclinical Systemic Inflammation
Arhiv za higijenu rada i toksikologiju, 68 (2017), 4; 276-286. https://doi.org/10.1515/aiht-2017-68-2965
Dalbello Tir, Alba Maria; Labor, Marina; Plavec, Davor

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Dalbello Tir, A. M., Labor, M. & Plavec, D. (2017). The Effects of Physical Activity on Chronic Subclinical Systemic Inflammation. Arhiv za higijenu rada i toksikologiju, 68. (4), 276-286. doi: 10.1515/aiht-2017-68-2965

Dalbello Tir, Alba Maria, et al. "The Effects of Physical Activity on Chronic Subclinical Systemic Inflammation." Arhiv za higijenu rada i toksikologiju, vol. 68, no. 4, 2017, pp. 276-286. https://doi.org/10.1515/aiht-2017-68-2965

Dalbello Tir, Alba Maria, Marina Labor and Davor Plavec. "The Effects of Physical Activity on Chronic Subclinical Systemic Inflammation." Arhiv za higijenu rada i toksikologiju 68, no. 4 (2017): 276-286. https://doi.org/10.1515/aiht-2017-68-2965

Dalbello Tir, A. M., Labor, M. and Plavec, D. (2017) 'The Effects of Physical Activity on Chronic Subclinical Systemic Inflammation', Arhiv za higijenu rada i toksikologiju, 68(4), pp. 276-286. doi: 10.1515/aiht-2017-68-2965

Dalbello Tir AM, Labor M, Plavec D. The Effects of Physical Activity on Chronic Subclinical Systemic Inflammation. Arhiv za higijenu rada i toksikologiju [Internet]. 2017 [cited 2024 December 07];68(4):276-286. doi: 10.1515/aiht-2017-68-2965

A. M. Dalbello Tir, M. Labor and D. Plavec, "The Effects of Physical Activity on Chronic Subclinical Systemic Inflammation", Arhiv za higijenu rada i toksikologiju, vol. 68, no. 4, pp. 276-286, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:580976. [Accessed: 07 December 2024]

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Metadata
Title (english)The Effects of Physical Activity on Chronic Subclinical Systemic Inflammation
Title (croatian)Učinci tjelesne aktivnosti na kroničnu subkliničku sustavnu upalu
AuthorAlba Maria Dalbello Tir
AuthorMarina Labor
MBZ: 357633
AuthorDavor Plavec
MBZ: 159962
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Chronic subclinical systemic inflammation (CSSI) is a pathogenic event and a common risk factor for many noncommunicable diseases like atherosclerosis, metabolic syndrome, cardiovascular disease, insulin resistance and type 2 diabetes, cancer, and obstructive lung disease. On the other hand, regular physical activity has been found to reduce this risk. Many studies of different design were conducted to assess the association between inflammatory mediators as markers of CSSI and regular physical activity. The aim of this review was to present the current level of evidence and understanding of potential mechanisms by which physical activity reduces inflammatory mediators involved in CSSI and the types of physical activity required for the expected effect. We have found that observational studies consistently report a positive association between regular physical activity and lower CSSI, but the design of these studies does not allow to infer a causal relationship. Interventional studies, in contrast, were not consistent about the causal relationship between regular physical activity and lower CSSI. The problem in interpreting these results lies in significant differences between these interventional studies in their design, sample size, study population, and intervention itself (intensity and extent, follow up, weight loss). We can conclude that the scientific community has to invest a significant effort into high-quality interventional trials focused on finding the type, intensity, and extent of physical activity that would produce the most favourable effect on CSSI.
Abstract (croatian)
Kronične nezarazne bolesti najznačajniji su javnozdravstveni problem. Kronična subklinička upala kao osnovni patološki supstrat zajednički je rizični čimbenik za većinu tih bolesti i stanja, kao što su arterioskleroza, metabolički sindrom, kardiovaskularne bolesti, rezistencija na inzulin i šećerna bolest tipa 2, novotvorine, opstruktivne plućne bolesti i mnoge druge. Nasuprot tomu, utvrđeno je da je redovita tjelesna aktivnost protektivni čimbenik u spomenutim bolestima. Provedene su mnoge studije različitoga dizajna s ciljem razotkrivanja povezanosti između kronične subkliničke upale i upalnih medijatora i redovite tjelesne aktivnosti. Cilj je ovog pregleda bio predočiti trenutačnu razinu dokaza te poimanja potencijalnih mehanizama u podlozi smanjenja kronične subkliničke upale kao posljedice redovite tjelesne aktivnosti, uključenih medijatora upale te oblika tjelesne aktivnosti potrebnih kako bi se postigao očekivani učinak. Utvrdili smo da su studije povezanosti predočile konzistentne dokaze u korist pozitivne povezanosti između redovite tjelesne aktivnosti i smanjenja kronične subkliničke upale. Dizajn tih studija ne dopušta zaključke o uzročno-posljedičnoj povezanosti ispitivanih fenomena. S druge strane, rezultati intervencijskih studija nisu konzistentni. Problem pri interpretaciji tih rezultata prouzročen je značajnom heterogenošću u dizajnu provedenih intervencijskih studija vezano uz veličinu uzorka, tip ispitanika te uz oblik intervencije (intenzitet i ekstenzitet tjelesne aktivnosti, trajanje intervencije, udruženost s gubitkom tjelesne mase). Na temelju trenutačne razine dokaza možemo zaključiti da je potrebno provesti više kvalitetnih intervencijskih studija radi definiranja tipa, intenziteta i ekstenziteta tjelesne aktivnosti koja će imati najznačajniji utjecaj na smanjenje kronične subkliničke upale.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArhiv za higijenu rada i toksikologiju
Numberingvol. 68, no. 4, pp. 276-286
p-ISSN0004-1254
e-ISSN1848-6312
DOIhttps://doi.org/10.1515/aiht-2017-68-2965
URN:NBNurn:nbn:hr:239:580976
Publication2017
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=281846
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0) icon
Created on2019-09-16 09:52:48