prikaz prve stranice dokumenta Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable
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Scientific paper - Original scientific paper
Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable
Collegium antropologicum, 39 (2015), 3; 735-743. urn:nbn:hr:239:092060
Šimetić, Lucija; Zibar, Lada; Drmić, Sandra; Begić, Ivana; Šerić, Vatroslav

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Šimetić, L., Zibar, L., Drmić, S., Begić, I. & Šerić, V. (2015). Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable. Collegium antropologicum, 39. (3), 735-743. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:092060

Šimetić, Lucija, et al. "Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable." Collegium antropologicum, vol. 39, no. 3, 2015, pp. 735-743. https://urn.nsk.hr/urn:nbn:hr:239:092060

Šimetić, Lucija, Lada Zibar, Sandra Drmić, Ivana Begić and Vatroslav Šerić. "Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable." Collegium antropologicum 39, no. 3 (2015): 735-743. https://urn.nsk.hr/urn:nbn:hr:239:092060

Šimetić, L., et al. (2015) 'Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable', Collegium antropologicum, 39(3), pp. 735-743. Available at: https://urn.nsk.hr/urn:nbn:hr:239:092060 (Accessed 09 December 2024)

Šimetić L, Zibar L, Drmić S, Begić I, Šerić V. Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable. Collegium antropologicum [Internet]. 2015 [cited 2024 December 09];39(3):735-743. Available at: https://urn.nsk.hr/urn:nbn:hr:239:092060

L. Šimetić, L. Zibar, S. Drmić, I. Begić and V. Šerić, "Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable", Collegium antropologicum, vol. 39, no. 3, pp. 735-743, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:092060. [Accessed: 09 December 2024]

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Metadata
Title (english)Creatinine Clearance and Estimated Glomerular Filtration Rate – When are they Interchangeable
Title (croatian)Klirens kreatinina i formule za računanje EGFR - Mogu li se koristiti naizmjenično?
AuthorLucija Šimetić
AuthorLada Zibar
MBZ: 254864
AuthorSandra Drmić
MBZ: 356586
AuthorIvana Begić
AuthorVatroslav Šerić
MBZ: 193563
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
Study goal was to examine which of glomerular rate equations is most suitable for prediction of creatinine clearance. Using a retrospective review of data from 500 hospital patients we calculated glomerular filtration rate according to Cockcroft-Gault equation (C-G), Modification of Diet in Renal Disease Study equation (MDRD) and Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). We determined if results of these equations were compatible with creatinine clearance, and does stage of kidney disease, body-mass index (BMI), diabetes or old age have an impact on their ability to predict creatinine clearance. All of the equations showed high correlations with creatinine clearance, regardless of diabetes, overweight or old age. There was no statistical difference (p<0.05) between diagnostic accuracy when comparing ROC plots for MDRD and CKD-EPI at creatinine clearance cut offs of 60 ml/min/1.73 m2 and 90 ml/min/1.73 m2 when analyzingdata for all subjects, older subjects (>65 years) and diabetics. The percentage of overweight subjects (BMI>25) in false positives (subjects with normal creatinine clearance and decreased GFR) was 64.8% for C-G, 88.6% for MDRD and 88.9% for CKD-EPI. Large number of overweight subjects with normal creatinine clearance and decreased GFR would indicate that creatinine clearance overestimates GFR in overweight subjects. Passing-Bablok regression showed agreement between creatinine clearance and MDRD and creatinine clearance and CKD-EPI only in cases of severely decreased GFR (G4 and G5 stage of chronic kidney disease). Only in these stages of chronic kidney disease can creatinine clearance and MDRD or creatinine clearance and CKD-EPI be used simultaneously.
Abstract (croatian)
Cilj studije bio je ispitati koja od formula za izračun stope glomerularne filtracije (eGFR, engl. estimated glomerulal filtration rate) je najkorisnija za predviđanje klirensa kreatinina. Koristeći retrospektivni pregled podataka za 500 bolničkih pacijenata izračunali smo stopu glomerularne filtracije prema formulama Cockcroft-Gault (C-G), Modification of Diet in Renal Disease Study equation (MDRD) i Chronic Kidney Disease Epidemiology Collaboration equation (CKD- EPI). Ispitali smo koliko su rezultati ovih triju formula usporedivi s klirensom kreatinina, te da li stadij bubrežne bolesti, indeks tjelesne mase (BMI, engl. body-mass index), dijabetes ili starija dob utječu na njihovu sposobnost predviđanja klirensa kreatinina. Sve ove formule su pokazale visoku korelaciju s klirensom kreatinina, neovisno o di- jabetesu, prekomjernoj tjelesnoj težini ili starijoj dobi. Nije postojala statistička razlika (p<0,05) između dijagnostičke točnosti pri usporedbi ROC krivulja za MDRD i CKD-EPI kod graničnih vrijednosti klirensa kreatinina od 60 ml/ min/1,73 m2 i 90 ml/min/1,73 m2 prilikom analize podataka za sve subjekte, starije subjekte (<65 godina) i dijabetičare. Postotak subjekata s povećanom tjelesnom težinom (BMI>25) u skupini lažno pozitivnih subjekata (onih s normalnim klirensom kreatinina i sniženim eGFR) bio je 64,8% za C-G, 88,6% za MDRD i 88,9% za CKD-EPI. Velik broj sub- jekata s povećanom tjelesnom težinom i normalnim klirensom kreatinina imao je snižen eGFR, što upućuje na to da klirens kreatinina precjenjuje GFR u subjekata s povećanom tjelesnom težinom. Passing-Bablok regresija je pokazala slaganje između klirensa kreatinina i MDRD, te klirensa kreatinina i CKD-EPI samo u slučajevima ozbiljnije sniženog GFR (G4 i G5 stadij kronične bubrežne bolesti). Samo u ovim stadijima kronične bubrežne bolesti klirens kreatinina i MDRD, te klirens kreatinina i CKD-EPI, se mogu koristiti simultano.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 39, no. 3, pp. 735-743
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:092060
Publication2015
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=245463
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-09-17 10:24:07