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Scientific paper - review paper
Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives
Current Drug Metabolism, 19 (2018), 10; 830-838. https://doi.org/10.2174/1389200219666180523095355
Kuna, Lucija; Božić, Ivana; Kizivat, Tomislav; Bojanić, Kristina; Mršo, Margareta; Kralj, Edgar; Smolić, Robert; Wue, George Y.; Smolić, Martina

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Kuna, L., Božić, I., Kizivat, T., Bojanić, K., Mršo, M., Kralj, E. ... Smolić, M. (2018). Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives. Current Drug Metabolism, 19. (10), 830-838. doi: 10.2174/1389200219666180523095355

Kuna, Lucija, et al. "Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives." Current Drug Metabolism, vol. 19, no. 10, 2018, pp. 830-838. https://doi.org/10.2174/1389200219666180523095355

Kuna, Lucija, Ivana Božić, Tomislav Kizivat, Kristina Bojanić, Margareta Mršo, Edgar Kralj, Robert Smolić, George Y. Wue and Martina Smolić. "Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives." Current Drug Metabolism 19, no. 10 (2018): 830-838. https://doi.org/10.2174/1389200219666180523095355

Kuna, L., et al. (2018) 'Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives', Current Drug Metabolism, 19(10), pp. 830-838. doi: 10.2174/1389200219666180523095355

Kuna L, Božić I, Kizivat T, Bojanić K, Mršo M, Kralj E, and sur.. Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives. Current Drug Metabolism [Internet]. 2018 [cited 2024 December 07];19(10):830-838. doi: 10.2174/1389200219666180523095355

L. Kuna, et al., "Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives", Current Drug Metabolism, vol. 19, no. 10, pp. 830-838, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:919465. [Accessed: 07 December 2024]

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Metadata
Title (english)Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives
AuthorLucija Kuna
MBZ: 353546
AuthorIvana Božić
AuthorTomislav Kizivat
AuthorKristina Bojanić
MBZ: 272625
AuthorMargareta Mršo
AuthorEdgar Kralj
AuthorRobert Smolić
MBZ: 292166
AuthorGeorge Y. Wue
AuthorMartina Smolić
MBZ: 292155
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
BACKGROUND: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases. METHODS: A structured search of bibliographic databases - Web of Science Core Collection, Scopus and Medline for peer-reviewed articles on models of DILI was performed. The reference lists of relevant studies was prepared and a citation search for the included studies was carried out. In addition, the characteristics of screened studies were described. RESULTS: One hundred and six articles about the existing knowledge of appropriate models to study DILI in vitro and in vivo with special focus on hepatic cell models, variations of 3D co-cultures, animal models, databases and predictive modeling and translational biomarkers developed to understand the mechanisms and pathophysiology of DILI are described. CONCLUSION: Besides descriptions of current applications of existing modeling systems, associated advantages and limitations of each modeling system and future directions for research development are discussed as well.
Keywords (english)
Languageenglish
Publication typeScientific paper - review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCurrent Drug Metabolism
Numberingvol. 19, no. 10, pp. 830-838
p-ISSN1389-2002
DOIhttps://doi.org/10.2174/1389200219666180523095355
URN:NBNurn:nbn:hr:239:919465
Publication2018
Document URLhttp://www.eurekaselect.com/162371/article
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-10-29 11:39:40