prikaz prve stranice dokumenta Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy
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Scientific paper - Original scientific paper
Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy
Kidney and Blood Pressure Research, 41 (2016), 6; 721-735. https://doi.org/10.1159/000450562
Mihalj, Martina; Tadžić, Refmir; Včev, Aleksandar; Ručević, Silvija; Drenjančević, Ines

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Mihalj, M., Tadžić, R., Včev, A., Ručević, S. & Drenjančević, I. (2016). Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy. Kidney and Blood Pressure Research, 41. (6), 721-735. doi: 10.1159/000450562

Mihalj, Martina, et al. "Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy." Kidney and Blood Pressure Research, vol. 41, no. 6, 2016, pp. 721-735. https://doi.org/10.1159/000450562

Mihalj, Martina, Refmir Tadžić, Aleksandar Včev, Silvija Ručević and Ines Drenjančević. "Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy." Kidney and Blood Pressure Research 41, no. 6 (2016): 721-735. https://doi.org/10.1159/000450562

Mihalj, M., et al. (2016) 'Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy', Kidney and Blood Pressure Research, 41(6), pp. 721-735. doi: 10.1159/000450562

Mihalj M, Tadžić R, Včev A, Ručević S, Drenjančević I. Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy. Kidney and Blood Pressure Research [Internet]. 2016 [cited 2024 December 10];41(6):721-735. doi: 10.1159/000450562

M. Mihalj, R. Tadžić, A. Včev, S. Ručević and I. Drenjančević, "Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy", Kidney and Blood Pressure Research, vol. 41, no. 6, pp. 721-735, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:280651. [Accessed: 10 December 2024]

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Metadata
Title (english)Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy
AuthorMartina Mihalj
MBZ: 322792
AuthorRefmir Tadžić
MBZ: 350034
AuthorAleksandar Včev
MBZ: 141721
AuthorSilvija Ručević
MBZ: 277480
AuthorInes Drenjančević
MBZ: 209603
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
BACKGROUND/AIMS: Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodium dismutase activity. This study aimed to investigate the effects of antihypertensive therapy and also vitamin C/E supplementation on BP, oxidative stress and endothelial activation in patients with essential hypertension. METHODS: Newly discovered patients received ARB/olmesartan or the Ca2+-channel blocker (CCB)/amlodipine, and additionally vitamin C/E or placebo throughout weeks 9-16. ELISA was used to determine 8-iso-prostaglendin F2-alpha (8iPGF2α) and endothelial activation markers. RESULTS: In both groups BP was normalized during first 8 weeks of therapy. Vitamins C/E had no additional BP-lowering effect. The vitamins C/E supplementation was not effective in reducing absolute values of 8iPGF2α; however; the magnitude of 8iPGF2α reduction was significantly greater in patients taking vitamins C/E in the CCB group. Although plasma 8iPGF2α positively correlated to BP, a significant decrease occurred during an additional 8 weeks of treatment. There were no changes in endothelial activation markers related to the specific action of ARB or CCB. CONCLUSIONS: Present study suggests that observed oxidative stress is a consequence of hypertension. BP reduction is associated with the observed decrease in oxidative stress and changes in endothelial activation regardless of antihypertensive therapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleKidney and Blood Pressure Research
Numberingvol. 41, no. 6, pp. 721-735
p-ISSN1420-4096
e-ISSN1423-0143
DOIhttps://doi.org/10.1159/000450562
URN:NBNurn:nbn:hr:239:280651
Publication2016
Document URLhttps://www.karger.com/Article/FullText/450562
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2019-10-31 08:13:50