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Professional paper - Review paper
Obesity Related Coronary Microvascular Dysfunction: from Basic to Clinical Practice
Cardiology Research and Practice, 2016 (2016); 1-7. https://doi.org/10.1155/2016/8173816
Selthofer-Relatić, Kristina; Bošnjak, I.; Kibel, Aleksandar

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Selthofer Relatić, K., Bošnjak, I. & Kibel, A. (2016). Obesity Related Coronary Microvascular Dysfunction: from Basic to Clinical Practice. Cardiology Research and Practice, 2016., 1-7. doi: 10.1155/2016/8173816

Selthofer Relatić, Kristina, et al. "Obesity Related Coronary Microvascular Dysfunction: from Basic to Clinical Practice." Cardiology Research and Practice, vol. 2016, 2016, pp. 1-7. https://doi.org/10.1155/2016/8173816

Selthofer Relatić, Kristina, I. Bošnjak and Aleksandar Kibel. "Obesity Related Coronary Microvascular Dysfunction: from Basic to Clinical Practice." Cardiology Research and Practice 2016 (2016): 1-7. https://doi.org/10.1155/2016/8173816

Selthofer Relatić, K., Bošnjak, I. and Kibel, A. (2016) 'Obesity Related Coronary Microvascular Dysfunction: from Basic to Clinical Practice', Cardiology Research and Practice, 2016, pp. 1-7. doi: 10.1155/2016/8173816

Selthofer Relatić K, Bošnjak I, Kibel A. Obesity Related Coronary Microvascular Dysfunction: from Basic to Clinical Practice. Cardiology Research and Practice [Internet]. 2016 [cited 2024 November 17];2016:1-7. doi: 10.1155/2016/8173816

K. Selthofer Relatić, I. Bošnjak and A. Kibel, "Obesity Related Coronary Microvascular Dysfunction: from Basic to Clinical Practice", Cardiology Research and Practice, vol. 2016, pp. 1-7, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:214684. [Accessed: 17 November 2024]

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Metadata
Title (english)Obesity Related Coronary Microvascular Dysfunction: from Basic to Clinical Practice
AuthorKristina Selthofer-Relatić
MBZ: 333024
AuthorI. Bošnjak
AuthorAleksandar Kibel
MBZ: 344370
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Obesity related coronary microvascular disease is a medical entity which is not yet fully elucidated. The pathophysiological basis of coronary microcirculatory dysfunction consists of a heterogeneous group of disorders with individual morphologic/functional/clinical presentation and prognosis. Coronary microcirculatory changes include mechanisms connected with vascular dysfunction, as well as extravascular and vasostructural changes in responses to neural, mechanical, and metabolic factors. Cardiometabolic changes that include obesity, dyslipidemia, diabetes mellitus type II, and hypertension are associated with atherosclerosis of epicardial coronary arteries and/or microvascular coronary dysfunction, with incompletely understood underlying mechanisms. In obesity, microvascular disease is mediated via adipokines/cytokines causing chronic, subclinical inflammation with (a) reduced NO-mediated dilatation, (b) changed endothelial- and smooth muscle-dependent vasoregulating mechanisms, (c) altered vasomotor control with increased sympathetic activity, and (d) obesity related hypertension with cardiomyocytes hypertrophy and impaired cardiac vascular adaptation to metabolic needs. From a clinical point of view it can present itself in acute or chronic form with different prognosis, as a practice problem for real-life diagnosis and treatment.
Languageenglish
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCardiology Research and Practice
Numberingvol. 2016, pp. 1-7
p-ISSN2090-8016
e-ISSN2090-0597
DOIhttps://doi.org/10.1155/2016/8173816
URN:NBNurn:nbn:hr:239:214684
Publication2016
Document URLhttps://www.hindawi.com/journals/crp/2016/8173816/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-12-03 07:53:40