prikaz prve stranice dokumenta The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA I
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Professional paper - Review paper
The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?
Frontiers in Physiology, 10 (2019), 1129; 1-19. https://doi.org/10.3389/fphys.2019.01129
Stupin, Marko; Kibel, Aleksandar; Stupin, Ana; Selthofer-Relatić, Kristina; Matić, Anita; Mihalj, Martina; Mihaljević, Zrinka; Jukić, Ivana; Drenjančević, Ines

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Stupin, M., Kibel, A., Stupin, A., Selthofer Relatić, K., Matić, A., Mihalj, M. ... Drenjančević, I. (2019). The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?. Frontiers in Physiology, 10. (1129), 1-19. doi: 10.3389/fphys.2019.01129

Stupin, Marko, et al. "The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?." Frontiers in Physiology, vol. 10, no. 1129, 2019, pp. 1-19. https://doi.org/10.3389/fphys.2019.01129

Stupin, Marko, Aleksandar Kibel, Ana Stupin, Kristina Selthofer Relatić, Anita Matić, Martina Mihalj, Zrinka Mihaljević, Ivana Jukić and Ines Drenjančević. "The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?." Frontiers in Physiology 10, no. 1129 (2019): 1-19. https://doi.org/10.3389/fphys.2019.01129

Stupin, M., et al. (2019) 'The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?', Frontiers in Physiology, 10(1129), pp. 1-19. doi: 10.3389/fphys.2019.01129

Stupin M, Kibel A, Stupin A, Selthofer Relatić K, Matić A, Mihalj M, and sur.. The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?. Frontiers in Physiology [Internet]. 2019 [cited 2024 November 16];10(1129):1-19. doi: 10.3389/fphys.2019.01129

M. Stupin, et al., "The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?", Frontiers in Physiology, vol. 10, no. 1129, pp. 1-19, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:684782. [Accessed: 16 November 2024]

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Title (english)The Physiological Effect of n-3 Polyunsaturated Fatty Acids (n-3 PUFAs) Intake and Exercise on Hemorheology, Microvascular Function, and Physical Performance in Health and Cardiovascular Diseases; Is There an Interaction of Exercise and Dietary n-3 PUFA Intake?
AuthorMarko Stupin
MBZ: 367386
AuthorAleksandar Kibel
MBZ: 344370
AuthorAna Stupin
MBZ: 322935
AuthorKristina Selthofer-Relatić
MBZ: 333024
AuthorAnita Matić
MBZ: 326344
AuthorMartina Mihalj
MBZ: 322792
AuthorZrinka Mihaljević
MBZ: 324952
AuthorIvana Jukić
AuthorInes Drenjančević
MBZ: 209603
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Nutritional Science
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Dietotherapy
Abstract (english)
Physical activity has a beneficial effect on systemic hemodynamics, physical strength, and cardiac function in cardiovascular (CV) patients. Potential beneficial effects of dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs), such as α-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid on hemorheology, vascular function, inflammation and potential to improve physical performance as well as other CV parameters are currently investigated. Recent meta-analysis suggests no effect of n-3 PUFA supplementation on CV function and outcomes of CV diseases. On the other hand, some studies support beneficial effects of n-3 PUFAs dietary intake on CV and muscular system, as well as on immune responses in healthy and in CV patients. Furthermore, the interaction of exercise and dietary n-3 PUFA intake is understudied. Supplementation of n-3 PUFAs has been shown to have antithrombotic effects (by decreasing blood viscosity, decreasing coagulation factor and PAI-1 levels and platelet aggregation/reactivity, enhancing fibrinolysis, but without effects on erythrocyte deformability). They decrease inflammation by decreasing IL-6, MCP-1, TNFα and hsCRP levels, expression of endothelial cell adhesion molecules and significantly affect blood composition of fatty acids. Treatment with n-3 PUFAs enhances brachial artery blood flow and conductance during exercise and enhances microvascular post-occlusive hyperemic response in healthy humans, however, the effects are unknown in cardiovascular patients. Supplementation of n-3 PUFAs may improve anaerobic endurance and may modulate oxygen consumption during intense exercise, may increase metabolic capacity, enhance endurance capacity delaying the onset of fatigue, and improving muscle hypertrophy and neuromuscular function in humans and animal models. In addition, n-3 PUFAs have anti-inflammatory and anti-nociceptive effects and may attenuate delayed-onset muscle soreness and muscle stiffness, and preserve joint mobility. On the other hand, effects of n-3 PUFAs were variably observed in men and women and they vary depending on dietary protocol, type of supplementation and type of sports activity undertaken, both in healthy and cardiovascular patients. In this review we will discuss the physiological effects of n-3 PUFA intake and exercise on hemorheology, microvascular function, immunomodulation and inflammation and physical performance in healthy persons and in cardiovascular diseases; elucidating if there is an interaction of exercise and diet.
Keywords (english)
Languageenglish
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Physiology
Numberingvol. 10, no. 1129, pp. 1-19
e-ISSN1664-042X
DOIhttps://doi.org/10.3389/fphys.2019.01129
URN:NBNurn:nbn:hr:239:684782
Publication2019
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728652/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-01-20 13:24:30