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Spontana HBsAg serokonverzija nakon dugogodišnje infekcije virusom hepatitisa B u pacijenta na kroničnoj hemodijalizi
Medicina Fluminensis : Medicina Fluminensis, 54 (2018), 2; 224-228. https://doi.org/10.21860/medflum2018_198206
Berlančić, Terezija; Zibar, Lada

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Berlančić, T. & Zibar, L. (2018). Spontana HBsAg serokonverzija nakon dugogodišnje infekcije virusom hepatitisa B u pacijenta na kroničnoj hemodijalizi. Medicina Fluminensis : Medicina Fluminensis, 54. (2), 224-228. doi: 10.21860/medflum2018_198206

Berlančić, Terezija and Lada Zibar. "Spontana HBsAg serokonverzija nakon dugogodišnje infekcije virusom hepatitisa B u pacijenta na kroničnoj hemodijalizi." Medicina Fluminensis : Medicina Fluminensis, vol. 54, no. 2, 2018, pp. 224-228. https://doi.org/10.21860/medflum2018_198206

Berlančić, Terezija and Lada Zibar. "Spontana HBsAg serokonverzija nakon dugogodišnje infekcije virusom hepatitisa B u pacijenta na kroničnoj hemodijalizi." Medicina Fluminensis : Medicina Fluminensis 54, no. 2 (2018): 224-228. https://doi.org/10.21860/medflum2018_198206

Berlančić, T. and Zibar, L. (2018) 'Spontana HBsAg serokonverzija nakon dugogodišnje infekcije virusom hepatitisa B u pacijenta na kroničnoj hemodijalizi', Medicina Fluminensis : Medicina Fluminensis, 54(2), pp. 224-228. doi: 10.21860/medflum2018_198206

Berlančić T, Zibar L. Spontana HBsAg serokonverzija nakon dugogodišnje infekcije virusom hepatitisa B u pacijenta na kroničnoj hemodijalizi. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2018 [cited 2024 April 19];54(2):224-228. doi: 10.21860/medflum2018_198206

T. Berlančić and L. Zibar, "Spontana HBsAg serokonverzija nakon dugogodišnje infekcije virusom hepatitisa B u pacijenta na kroničnoj hemodijalizi", Medicina Fluminensis : Medicina Fluminensis, vol. 54, no. 2, pp. 224-228, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:359271. [Accessed: 19 April 2024]

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Metadata
Title (croatian)Spontana HBsAg serokonverzija nakon dugogodišnje infekcije virusom hepatitisa B u pacijenta na kroničnoj hemodijalizi
Title (english)Spontaneous hepatitis B surface antigen seroconversion after long lasting hepatitis B virus infection in a chronic hemodialysis patient
AuthorTerezija Berlančić
AuthorLada Zibar
MBZ: 254864
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (croatian)
Cilj: Cilj je prikazati neobičan spontani nestanak HBsAg nakon dugotrajne infekcije. Prikaz slučaja: Dvadesetšestogodišnji muškarac započeo je kroničnu hemodijalizu (HD) 1994. godine zbog kroničnog glomerulonefritisa. Serološka analiza bila je pozitivna na infekciju virusom hepatitisa B (VHB). Tijekom sljedećih godina liječen je HD-om i njegovi su biljezi VHB ostali nepromijenjeni (HBsAg pozitivnost). Kada je antivirusna terapija postala dostupna, pacijent je odbio liječenje. HBsAg postao je 2006. negativan po prvi put u 12 godina, dok su anti-HBs i anti-HBc postali pozitivni, što bi upućivalo na to da je nakon prirodne infekcije razvio imunost. Do sada su sve ponovljene pretrage negativne za HBsAg. 2008. godine transplantiran mu je bubreg od mrtvog darovatelja i uvedena terapija imunosupresivima (IS). Tijekom liječenja IS-om, koja je u tijeku, bio je stabilan i bez HBV viremije (HBsAg negativno). Zaključak: Još uvijek nije jasno kako se spontana HBsAg serokonverzija dogodila u našeg bolesnika nakon dugotrajne infekcije. Također je zanimljivo da su i 11 godina nakon serokonverzije njegovi biljezi VHB-a još uvijek nepromijenjeni (HBsAg negativnost) i pokazuju znakove preboljele infekcije VHB-om, unatoč devetogodišnjem IS-u zbog bubrežnog presađivanja. Moguće je da su njegove razine anti-HBs dovoljno visoke da ga zaštite i inhibiraju reaktivaciju VHB-a ili virus uopće nije prisutan u njegovim hepatocitima.
Abstract (english)
Aim: The aim was to present an unusual spontaneous disappearance of HBsAg after a long-lasting infection. Case report: A 26-year-old man started chronic hemodialysis (HD) in 1994 for chronic glomerulonephritis. Serological analysis was positive for hepatitis B virus (HBV) infection. During the following years he was treated with HD and his HBV markers remained unchanged (HBsAg positivity). When antiviral therapy became available the patient refused to be treated. In 2006 his HBsAg became negative for the first time in 12 years, while anti-HBs and anti-HBc became positive, which would indicate that he became immune late after a natural infection. To date, all repeated check-ups have been negative for HBsAg. In 2008 he received a kidney transplant from a deceased donor and was put on immunosuppressive (IS) therapy. During the IS treatment, which is ongoing, he has been stable and without HBV viremia (HBsAg-negative). Conclusion: It has still remained unclear how spontaneous HBsAg seroconversion did happen in our patient after long lasting infection. It has also been interesting that 11 years after seroconversion his HBV markers have still been unchanged (HBsAg negativity) and show signs of a resolved HBV infection, even though he has been immunosuppressed due to kidney transplantation for already 9 years. It is possible that his anti-HBs levels are high enough to protect him and inhibit HBV reactivation or the virus has not been dormant in his hepatic cells at all.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeOther - Review
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 54, no. 2, pp. 224-228
p-ISSN1847-6864
e-ISSN1848-820X
DOIhttps://doi.org/10.21860/medflum2018_198206
URN:NBNurn:nbn:hr:239:359271
Publication2018
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=291948
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2019-09-13 11:03:19