prikaz prve stranice dokumenta The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience
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Scientific paper - Original scientific paper
The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience
Medicinski glasnik, 16 (2019), 1; 53-59. https://doi.org/10.17392/994-19
Muller, Andrijana; Horvat, Vesna; Vulin, Martina; Mandić, Sanja; Šerić, Vatroslav; Vidosavljević, Domagoj

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Muller, A., Horvat, V., Vulin, M., Mandić, S., Šerić, V. & Vidosavljević, D. (2019). The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience. Medicinski glasnik, 16. (1), 53-59. doi: 10.17392/994-19

Muller, Andrijana, et al. "The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience." Medicinski glasnik, vol. 16, no. 1, 2019, pp. 53-59. https://doi.org/10.17392/994-19

Muller, Andrijana, Vesna Horvat, Martina Vulin, Sanja Mandić, Vatroslav Šerić and Domagoj Vidosavljević. "The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience." Medicinski glasnik 16, no. 1 (2019): 53-59. https://doi.org/10.17392/994-19

Muller, A., et al. (2019) 'The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience', Medicinski glasnik, 16(1), pp. 53-59. doi: 10.17392/994-19

Muller A, Horvat V, Vulin M, Mandić S, Šerić V, Vidosavljević D. The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience. Medicinski glasnik [Internet]. 2019 [cited 2024 November 16];16(1):53-59. doi: 10.17392/994-19

A. Muller, V. Horvat, M. Vulin, S. Mandić, V. Šerić and D. Vidosavljević, "The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience", Medicinski glasnik, vol. 16, no. 1, pp. 53-59, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:582124. [Accessed: 16 November 2024]

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Metadata
Title (english)The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience
AuthorAndrijana Muller
MBZ: 294701
AuthorVesna Horvat
MBZ: 349024
AuthorMartina Vulin
AuthorSanja Mandić
MBZ: 349013
AuthorVatroslav Šerić
MBZ: 193563
AuthorDomagoj Vidosavljević
MBZ: 323012
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract (english)
Aim To investigate a potential of the clinical use of the soluble fms-like tyrosine kinase 1 (sFLT-1) to placental growth factor (PlGF) ratio from the perspective of a small hospital centre. Methods Maternal serum samples were analysed at 241/7-28 0/7, and 281/7-320/7 weeks of gestation. The level of sFLT-1 and PIGF was determined by immunoassay platform and used to calculate the sFLT-1/PIGF ratio in 35 pregnant women, and divided into subgroups according to preeclampsia occurrence at the time of delivery: preterm (≤37 weeks) or term (37-42 weeks'), and matched a control group. Results Patients in the preterm delivery group had a significantly higher incidence of intrauterine growth restriction, lower gestational age at the time of delivery, and lower infant birth weight compared to the other two groups. There was a negative correlation between the sFLT-1/PlGF ratio and GA and between the sFLT-1/ PlGF ratio and birth weight at the time of delivery. The value of the sFLT-1/PlGF ratio was significantly higher in the preterm delivery PE group. All the PE group pregnancies ended with caesarean delivery compared to 25% in the control group. However, none of the patients from the PE group had any of the possible complications of preeclampsia nor did they require additional therapy such as blood transfusion or additional non-standard hypertensive therapy. Conclusion The sFLT-1/PlGF ratio could be used as an indicator for the development and estimation of the severity of PE to provide objective evidence for the management of preeclampsia patients, and as a predictive marker of preeclampsia at low cost.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedicinski glasnik
Numberingvol. 16, no. 1, pp. 53-59
p-ISSN1840-0132
e-ISSN1840-2445
DOIhttps://doi.org/10.17392/994-19
URN:NBNurn:nbn:hr:239:582124
Publication2019
Document URLhttp://ljkzedo.ba/mg30/19-Muller-994-A.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-ShareAlike 4.0 International (CC BY-SA 4.0) icon
Created on2020-05-15 09:35:28