prikaz prve stranice dokumenta Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population
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Scientific paper - Original scientific paper
Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population
Collegium antropologicum, 38 (2014), 4; 393-400. urn:nbn:hr:239:181246
Horvat, Vesna; Mandić, Sanja; Marczi, Saška; Mrčela, Milanka; Galić, Josip

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Horvat, V., Mandić, S., Marczi, S., Mrčela, M. & Galić, J. (2014). Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population. Collegium antropologicum, 38. (4), 393-400. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:181246

Horvat, Vesna, et al. "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population." Collegium antropologicum, vol. 38, no. 4, 2014, pp. 393-400. https://urn.nsk.hr/urn:nbn:hr:239:181246

Horvat, Vesna, Sanja Mandić, Saška Marczi, Milanka Mrčela and Josip Galić. "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population." Collegium antropologicum 38, no. 4 (2014): 393-400. https://urn.nsk.hr/urn:nbn:hr:239:181246

Horvat, V., et al. (2014) 'Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population', Collegium antropologicum, 38(4), pp. 393-400. Available at: https://urn.nsk.hr/urn:nbn:hr:239:181246 (Accessed 16 November 2024)

Horvat V, Mandić S, Marczi S, Mrčela M, Galić J. Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population. Collegium antropologicum [Internet]. 2014 [cited 2024 November 16];38(4):393-400. Available at: https://urn.nsk.hr/urn:nbn:hr:239:181246

V. Horvat, S. Mandić, S. Marczi, M. Mrčela and J. Galić, "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population", Collegium antropologicum, vol. 38, no. 4, pp. 393-400, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:181246. [Accessed: 16 November 2024]

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Metadata
Title (english)Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population
Title (croatian)Povezanost il-1b i il-10 polimorfizama s rizikom i progresijom raka prostate u populaciji istočne Hrvatske
AuthorVesna Horvat
MBZ: 349024
AuthorSanja Mandić
MBZ: 349013
AuthorSaška Marczi
MBZ: 254853
AuthorMilanka Mrčela
MBZ: 224701
AuthorJosip Galić
Author's institution(Clinical hospital center Osijek)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Single nuclear polymorphisms (SNPs) in the promotor regions of cytokine genes included in angiogenesis may influence prostate cancer (PCa) development via regulation of the pathways of tumor angiogenesis. The aim of the present study was to investigate the association of IL-1β+3954 (rs1143634) and IL-10-1082 (rs1800896) polymorphisms with PCa risk and aggressiveness in eastern Croatian patients. One hundred twenty PCa patients and 120 benign prostatic hyperplasia (BPH) controls were genotyped using real-time PCR (LightCycler Instrument, Roche Diagnostics) and the melting curve analysis method. There was no significant difference in the frequency of genotypes for the two polymorphisms between PCa patients and controls (χ2=0.857, p=0.355 for IL-β1; χ2=0.026, p=0.872 for IL-10). Carriers of the IL-10-1082A>G variant were found to be associated with the Gleason score (GS)>7 (AA versus GA+GG, OR=3.47, 95% CI 1.11-10.88, p=0.033). There was no significant difference in the frequency of genotypes for the two polymorphisms and the presence of metastatic disease in PCa patients. These results suggest that tested SNPs associated with differential production of IL-1β and IL-10 are not risk factors for PCa and do not correlate with the presence of distant metastasis in eastern Croatians. We found that IL-10-1082 GA+/or GG carriers have a higher risk of developing PCa with GS>7 in eastern Croatians.
Abstract (croatian)
Pojedinačni nuklearni polimorfi zmi (SNP) u promotorskim regijama gena citokina uključenih u angiogenezu, mogu utjecati na razvoj karcinoma prostate (PCa) regulacijom putova angiogeneze tumora. Cilj ove studije bio je istražiti povezanost IL-1b+3954 (rs1143634) i IL-10-1082 (rs1800896) polimorfi zama s rizikom i agresivnošću karcinoma prostate kod pacijenata iz istočne Hrvatske. 120 pacijenata s karcinomom prostate i 120 kontrola s benignom hiperplazijom prostate (BPH) genotipizirani su metodom lančane reakcije polimerazom u stvarnom vremenu (eng. real-time PCR) i analizom krivulje temperature taljenja pomoću tehnologije LightCycler (Roche Diagnostics). Nije bilo značajne razlike u učestalosti genotipova za dva polimorfi zma između PCa bolesnika i kontrola (c2=0,857, p=0,355 za IL-b1; c2=0,026, p=0,872 za IL-10). Utvrđena je povezanost nosioca IL-10-1082A>G varijante s GS>7 (AA u odnosu na GA+GG, OR=3,47; 95% CI 1.11 do 10,88, p=0,033). Nije bilo značajne razlike u učestalosti genotipova za dva polimorfi zma i prisutnosti metastatske bolesti u PCa bolesnika. Ovi rezultati sugeriraju da testirani SNP-ovi, povezani s različitom produkcijom IL-1b i IL-10, nisu čimbenici rizika za PCa i ne koreliraju s prisutnošću metastaza kod ispitanika u istočnoj Hrvatskoj. Otkrili smo da u istočnoj Hrvatskoj, nositelji IL-10-1082 GA +/ili GG genotipa imaju veći rizik razvoja PCa s GS>7.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 38, no. 4, pp. 393-400
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:181246
Publication2014
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=245096
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-15 10:02:28