prikaz prve stranice dokumenta Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy
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Scientific paper - Original scientific paper
Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy
Collegium antropologicum, 38 (2014), 1; 147-150. urn:nbn:hr:239:525581
Miličević, Nevenka; Mrčela, Milanka; Lukić, Ivan; Mandić, Sanja; Horvat, Vesna; Galić, Josip

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Miličević, N., Mrčela, M., Lukić, I., Mandić, S., Horvat, V. & Galić, J. (2014). Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy. Collegium antropologicum, 38. (1), 147-150. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:525581

Miličević, Nevenka, et al. "Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy." Collegium antropologicum, vol. 38, no. 1, 2014, pp. 147-150. https://urn.nsk.hr/urn:nbn:hr:239:525581

Miličević, Nevenka, Milanka Mrčela, Ivan Lukić, Sanja Mandić, Vesna Horvat and Josip Galić. "Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy." Collegium antropologicum 38, no. 1 (2014): 147-150. https://urn.nsk.hr/urn:nbn:hr:239:525581

Miličević, N., et al. (2014) 'Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy', Collegium antropologicum, 38(1), pp. 147-150. Available at: https://urn.nsk.hr/urn:nbn:hr:239:525581 (Accessed 12 December 2024)

Miličević N, Mrčela M, Lukić I, Mandić S, Horvat V, Galić J. Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy. Collegium antropologicum [Internet]. 2014 [cited 2024 December 12];38(1):147-150. Available at: https://urn.nsk.hr/urn:nbn:hr:239:525581

N. Miličević, M. Mrčela, I. Lukić, S. Mandić, V. Horvat and J. Galić, "Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy", Collegium antropologicum, vol. 38, no. 1, pp. 147-150, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:525581. [Accessed: 12 December 2024]

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Metadata
Title (english)Comparison Between Clinical Significance of Serum Proinflammatory Protein Interleukin-6 and Classic Tumor Markers Total PSA, Free PSA and Free/Total PSA Prior to Prostate Biopsy
Title (croatian)Usporedba kliničke značajnosti proinflamatornog proteina interleukina-6 u serumu i klasičnih tumorskih markera ukupnog psa, slobodnog psa i slobodni/ukupni psa prije biopsije prostate
AuthorNevenka Miličević
MBZ: 357655
AuthorMilanka Mrčela
MBZ: 224701
AuthorIvan Lukić
MBZ: 358140
AuthorSanja Mandić
MBZ: 349013
AuthorVesna Horvat
MBZ: 349024
AuthorJosip Galić
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
The aim of the study was to clarify whether serum levels of proinflammatory cytokine interleukin-6 (IL-6) could be a useful marker in prostate diseases. Serum IL-6 was determined prior to prostate biopsy procedure in 82 patients with prostate adenocarcinoma (PCa), 25 patients with benign prostatic hyperplasia (BPH), 24 patients with high-grade prostatic intraepithelial neoplasia (PIN) and 17 patients with chronic prostatitis. Serum IL-6 levels were compared with total PSA (tPSA), free PSA (fPSA) and the free/total ratio (f/tPSA) serum levels. Statistically significant difference was not found in serum IL-6 levels among the four groups (p=0.088). However, the patients with poorly differentiated PCa with Gleason score (GS) 4+3=7 and >7 had significantly higher serum IL-6 levels than the patients with moderately differentiated PCa with GS 3+4=7 and <7 (p=0.007). The findings suggest that serum IL-6 level might be a potentially useful marker for poorly differentiated PCa.
Abstract (croatian)
Cilj ove studije je bio razjasniti može li razina proinflamatornog citokina, interleukina-6 (IL-6) u serumu biti korisni marker kod bolesti prostate. Serumski IL-6 je bio određen prije biopsije prostate u 82 pacijenta s adenokarcinomom prostate (PCa), 25 pacijenata s benignom hiperplazijom prostate (BPH), 24 pacijenta s intraepitelnom neoplazijom visokog stupnja (PIN) i 17 pacijenata s kroničnim prostatitisom. Razina serumskog IL-6 je uspore|ena s ukupnim PSA (tPSA), slobodnim PSA (fPSA) i omjerom slobodni/totalni PSA (f/tPSA) u serumu. Statistički značajna razlika nije nađena u razini serumskog IL-6 između četiri grupe (p=0.088). Međutim, pacijenti s loše diferenciranim PCa s Gleason »scoreom« (GS) 4+3=7 i >7 imali su značajno više razine serumskog IL-6 nego pacijenti sa srednje diferenciranim PCa s GS 3+4=7 i <7 (p=0.007). Rezultati sugeriraju da bi razina serumskog IL-6 mogla biti potencijalni korisni marker kod slabo diferenciranog PCa.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 38, no. 1, pp. 147-150
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:525581
Publication2014
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=178795
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-15 10:43:33