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Scientific paper - Original scientific paper
Vitamin K Epoxide Reductase Complex 1 (VKORC1) Gene Polymorphisms in Population of Eastern Croatia
Collegium antropologicum, 37 (2013), 4; 1321-1326. urn:nbn:hr:239:170125
Mandić, Dario; Mandić, Sanja; Horvat, Vesna; Samardžija, Marina; Samardžija, Marko

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Mandić, D., Mandić, S., Horvat, V., Samardžija, M. & Samardžija, M. (2013). Vitamin K Epoxide Reductase Complex 1 (VKORC1) Gene Polymorphisms in Population of Eastern Croatia. Collegium antropologicum, 37. (4), 1321-1326. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:170125

Mandić, Dario, et al. "Vitamin K Epoxide Reductase Complex 1 (VKORC1) Gene Polymorphisms in Population of Eastern Croatia." Collegium antropologicum, vol. 37, no. 4, 2013, pp. 1321-1326. https://urn.nsk.hr/urn:nbn:hr:239:170125

Mandić, Dario, Sanja Mandić, Vesna Horvat, Marina Samardžija and Marko Samardžija. "Vitamin K Epoxide Reductase Complex 1 (VKORC1) Gene Polymorphisms in Population of Eastern Croatia." Collegium antropologicum 37, no. 4 (2013): 1321-1326. https://urn.nsk.hr/urn:nbn:hr:239:170125

Mandić, D., et al. (2013) 'Vitamin K Epoxide Reductase Complex 1 (VKORC1) Gene Polymorphisms in Population of Eastern Croatia', Collegium antropologicum, 37(4), pp. 1321-1326. Available at: https://urn.nsk.hr/urn:nbn:hr:239:170125 (Accessed 17 November 2024)

Mandić D, Mandić S, Horvat V, Samardžija M, Samardžija M. Vitamin K Epoxide Reductase Complex 1 (VKORC1) Gene Polymorphisms in Population of Eastern Croatia. Collegium antropologicum [Internet]. 2013 [cited 2024 November 17];37(4):1321-1326. Available at: https://urn.nsk.hr/urn:nbn:hr:239:170125

D. Mandić, S. Mandić, V. Horvat, M. Samardžija and M. Samardžija, "Vitamin K Epoxide Reductase Complex 1 (VKORC1) Gene Polymorphisms in Population of Eastern Croatia", Collegium antropologicum, vol. 37, no. 4, pp. 1321-1326, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:170125. [Accessed: 17 November 2024]

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Metadata
Title (english)Vitamin K Epoxide Reductase Complex 1 (VKORC1) Gene Polymorphisms in Population of Eastern Croatia
Title (croatian)Polimorfizmi vitamin K epoksid reduktaza kompleks 1 (vkorc1) gena u populaciji istočne Hrvatske
AuthorDario Mandić
MBZ: 367140
AuthorSanja Mandić
MBZ: 349013
AuthorVesna Horvat
MBZ: 349024
AuthorMarina Samardžija
MBZ: 269264
AuthorMarko Samardžija
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Vitamin K epoxide reductase (VKOR) is a key enzyme in the g-carboxylation of proteins associated with important bodily functions (coagulation, bone metabolism, etc.). This feature is particularly used in warfarin therapy, which blocks the VKOR enzyme and leads to production of dysfunctional coagulation proteins. Genetic factors, particularly vitamin K epoxide reductase complex 1 (VKORC1) gene, have greatest influence on warfarin therapy. The aim of this study was to determine the distribution of VKORC1 1173C>T and VKORC1 -1639G>A polymorphisms, which are most important for warfarin therapy. We investigated 420 unrelated healthy individuals, mostly blood donors, from region of the Eastern Croatia. Both investigated polymorphisms were in perfect linkage disequilibrium (LD) and showed identical results. 151 patients (36%) were homozygous for the wild-type (C/C and G/G), 196 (47%) were heterozygous (C/T and G/A) and 73 (17%) were homozygous for the variant allele (T/T and A/A). Number of normal alleles among individuals was 498 (59.3%), and number of variant alleles was 342 (40.7%). The data obtained are in good agreement with the results of studies in other European populations.
Abstract (croatian)
Vitamin K epoksid reduktaza (VKOR) je ključan enzim u g-karboksilaciji proteina povezanih s važnim tjelesnim funkcijama (koagulacija, metabolizam kostiju i dr.). Ta značajka je posebno iskorištena u terapiji varfarinom koja blokira VKOR enzim i uzrokuje stvaranje nefunkcionalnih koagulacijskih proteina. Na terapiju varfarinom najveći utjecaj imaju genetski čimbenici, posebno vitamin K epoksid reduktaza kompleks 1 (VKORC1) gen. Cilj ovog istraživanja bio je utvrditi raspodjelu dvaju polimorfizama najznačajnijih za terapiju varfarinom: VKORC1 1173C>T i VKORC1 -1639G>A. Ispitano je 420 zdravih osoba, pretežno dobrovoljnih davatelja krvi, iz područja istočne Hrvatske. Rezultati su pokazali da su oba ispitivana polimorfizma u savršenoj neravnoteži povezanosti (eng. linkage disequilibrium – LD) i pokazali su identične rezultate. Za 151 ispitanika (36%) potvrđeno je da su homozigoti za divlji tip (C/C i G/G), 196 ispitanika (47%) su heterozigoti (C/T i G/A) a 73 (17%) su homozigoti za varijantni alel (T/T i A/A). Broj normalnih alela me|u ispitanicima bio je 498 (59,3%), dok je varijantnih alela pronađeno 342 (40,7%). Dobiveni podaci se dobro slažu s rezultatima studija u drugim Europskim populacijama.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 37, no. 4, pp. 1321-1326
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:170125
Publication2013
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=174987
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-18 08:17:52