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Scientific paper - Original scientific paper
Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia
Collegium antropologicum, 37 (2013), 3; 907-911. urn:nbn:hr:239:509162
Mandić, Sanja; Sudarević, Bojan; Marczi, Saška; Horvat, Vesna; Ćosić, Ivan; Mihaljević, Slobodan; Miličević, Nevenka; Šimunović, Dalibor; Galić, Josip

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Mandić, S., Sudarević, B., Marczi, S., Horvat, V., Ćosić, I., Mihaljević, S. ... Galić, J. (2013). Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia. Collegium antropologicum, 37. (3), 907-911. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:509162

Mandić, Sanja, et al. "Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia." Collegium antropologicum, vol. 37, no. 3, 2013, pp. 907-911. https://urn.nsk.hr/urn:nbn:hr:239:509162

Mandić, Sanja, Bojan Sudarević, Saška Marczi, Vesna Horvat, Ivan Ćosić, Slobodan Mihaljević, Nevenka Miličević, Dalibor Šimunović and Josip Galić. "Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia." Collegium antropologicum 37, no. 3 (2013): 907-911. https://urn.nsk.hr/urn:nbn:hr:239:509162

Mandić, S., et al. (2013) 'Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia', Collegium antropologicum, 37(3), pp. 907-911. Available at: https://urn.nsk.hr/urn:nbn:hr:239:509162 (Accessed 26 October 2024)

Mandić S, Sudarević B, Marczi S, Horvat V, Ćosić I, Mihaljević S, and sur.. Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia. Collegium antropologicum [Internet]. 2013 [cited 2024 October 26];37(3):907-911. Available at: https://urn.nsk.hr/urn:nbn:hr:239:509162

S. Mandić, et al., "Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia", Collegium antropologicum, vol. 37, no. 3, pp. 907-911, 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:509162. [Accessed: 26 October 2024]

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Metadata
Title (english)Interleukin-6 Polymorphism and Prostate Cancer Risk in Population of Eastern Croatia
Title (croatian)Polimorfizam interleukina-6 i rizik od karcinoma prostate u populaciji istočne Hrvatske
AuthorSanja Mandić
MBZ: 349013
AuthorBojan Sudarević
MBZ: 287852
AuthorSaška Marczi
MBZ: 254853
AuthorVesna Horvat
MBZ: 349024
AuthorIvan Ćosić
AuthorSlobodan Mihaljević
MBZ: 234050
AuthorNevenka Miličević
MBZ: 357655
AuthorDalibor Šimunović
MBZ: 335976
AuthorJosip Galić
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Recent studies suggest that chronic inflammation is crucial in the development and progression of prostate cancer (CaP). Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in intraprostatic inflammation and thus carcinogenesis. The –174G>C polymorphism of IL-6 gene has been associated with high IL-6 producer pheno- type and an increased risk for CaP . The aim of this study was to evaluate the association between the mentioned IL-6 polymorphism and CaP risk, as well as to compare the genotype frequency between the different tumour grades of CaP , in population of Eastern Croatia. We analyzed the IL-6 polymorphism in 120 CaP patients and 120 controls with benign prostatic hyperplasia (BPH). CaP patients and BPH controls did not statistically differ in studied IL-6 polymorphism. Furthermore, high IL-6 producer genotypes (GG or GC) were more frequent in controls than in CaP group (86.7% vs 80.8%, respectively, p=0.147). Also, no statistically significant difference in IL-6 high and low producer genotype fre- quency was noticed between well, moderately and poorly differentiated tumours. Our results, taken together with other studies on the subject, suggest that IL-6 – 174 single nucleotide polymorphism (SNP) distribution may differ between various ethnic groups and that a single cytokine gene polymorphism has probably just a minor effect on CaP susceptibil- ity. Further studies should be performed to clarify the link between SNPs of different cytokines and the risk for CaP .
Abstract (croatian)
Novija istraživanja navode kroničnu upalu kao ključni čimbenik u nastanku i progresiji karcinoma prostate (CaP). Interleukin-6 (IL-6) je proinflamatorni citokin koji ima važnu ulogu u upali prostate, a prema tome i u karcinogenezi. –147G>C polimorfizam IL-6 gena se povezuje s fenotipom visoke produkcije IL-6 i pove}anim rizikom za CaP. Cilj ovog istraživanja bio je ispitati povezanost između navedenog IL-6 polimorfizma i rizika za razvoj CaP, kao i usporediti frekvenciju genotipova između različitih stadija karcinoma prostate, u populaciji Istočne Hrvatske. Ispitali smo polimorfizam IL-6 u 120 pacijenata s CaP i 120 kontrolnih subjekata s benignom hiperplazijom prostate (BPH). Pacijenti s CaP se u ispitivanom polimorfizmu IL-6 nisu statistički razlikovali od kontrola s BPH. Štoviše, genotipovi visoke produkcije IL-6 (GG ili GC) bili su učestaliji u kontrolnoj grupi nego u grupi s CaP (86,7% naspram 80,8%, p=0,147). Osim toga, značajna razlika u raspodjeli genotipova visoke i niske produkcije nije nađena niti između dobro, srednje i slabo diferenciranih tumora. Naši rezultati, ako se uzmu u obzir i ostale studije o istoj temi, navode na zaključak da bi se raspodjela polimorfizma IL-6-174 mogla razlikovati među različitim etničkim skupinama i da polimorfizam jednog nukleotida gena za citokine vjerojatno ima samo manji utjecaj na podložnost razvoja CaP. Potrebna su daljnja istraživanja kako bi se pojasnila poveznica između polimorfizama gena različitih citokina i rizika za CaP.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 37, no. 3, pp. 907-911
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:509162
Publication2013
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=174827
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-18 08:50:25