prikaz prve stranice dokumenta Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification
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Scientific paper - Original scientific paper
Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification
Collegium antropologicum, 30 (2006), 1; 137-142. urn:nbn:hr:239:754555
Pajtler, Marija; Audy-Jurković, Silvana; Miličić-Juhas, Valerija; Staklenac, Blaženka; Pauzar, Biljana

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Pajtler, M., Audy Jurković, S., Miličić Juhas, V., Staklenac, B. & Pauzar, B. (2006). Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification. Collegium antropologicum, 30. (1), 137-142. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:754555

Pajtler, Marija, et al. "Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification." Collegium antropologicum, vol. 30, no. 1, 2006, pp. 137-142. https://urn.nsk.hr/urn:nbn:hr:239:754555

Pajtler, Marija, Silvana Audy Jurković, Valerija Miličić Juhas, Blaženka Staklenac and Biljana Pauzar. "Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification." Collegium antropologicum 30, no. 1 (2006): 137-142. https://urn.nsk.hr/urn:nbn:hr:239:754555

Pajtler, M., et al. (2006) 'Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification', Collegium antropologicum, 30(1), pp. 137-142. Available at: https://urn.nsk.hr/urn:nbn:hr:239:754555 (Accessed 17 November 2024)

Pajtler M, Audy Jurković S, Miličić Juhas V, Staklenac B, Pauzar B. Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification. Collegium antropologicum [Internet]. 2006 [cited 2024 November 17];30(1):137-142. Available at: https://urn.nsk.hr/urn:nbn:hr:239:754555

M. Pajtler, S. Audy Jurković, V. Miličić Juhas, B. Staklenac and B. Pauzar, "Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification", Collegium antropologicum, vol. 30, no. 1, pp. 137-142, 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:754555. [Accessed: 17 November 2024]

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Title (english)Interobserver Variability in Cytologic Subclassification of Squamous Intraepithelial Lesions – The Bethesda System vs. World Health Organization Classification
Title (croatian)Interobserver varijabilnost u citološkoj subklasifikaciji skvamoznih intraepitelnih lezija
AuthorMarija Pajtler
MBZ: 104562
AuthorSilvana Audy-Jurković
MBZ: 78284
AuthorValerija Miličić-Juhas
MBZ: 312791
AuthorBlaženka Staklenac
MBZ: 205590
AuthorBiljana Pauzar
MBZ: 209910
Author's institution(Clinical hospital center Osijek)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Cytology
Abstract (english)
The aim of the study was to compare interobserver variability for The Bethesda System (TBS) and World Health Organization (WHO) classification of cervical squamous intraepithelial lesions. A total of 1,000 conventional Papanicolaou smears (156 positive and 884 negative) were examined »blindly« by three cytologists and one cytotechnician. The degree of observer agreement was expressed by kappa statistics using a program for the calculation of interobserver variation and association »Agree« (Svanholm and Jergensen, 1989). Kappa (x) was determined for each cytologic diagnosis within a particular classification and total for either classification. The association with and separation from other diagnoses was determined for each cytologic diagnosis in the form of conditional probability (Pj). In WHO classification, the diagnoses of dysplasia media and dysplasia gravis showed poor reproducibility (x=0.114 and x= 0.259, respectively), the diagnosis of dysplasia levis good reproducibility (x=0.639), and the diagnosis of carcinoma in situ excellent reproducibility (x=0.762). WHO classification yielded pool x of 0.741. In TBS classification, the diagnosis of LSIL showed good, and HSIL excellent reproducibility (x=0.542 and x=0.763, respectively). TBS classification yielded pool x of 0.699. Dysplasia media (Pj=0.121) and dysplasia gravis (Pj=0.274) were found to be morphologically poorly defined, and carcinoma in situ (Pj=0.777) and dysplasia levis (Pj=0.651) well defined diagnoses. LSIL was morphologically moderately defined (Pj=0.587) and HSIL well defined (Pj=0.789) diagnosis. Accordingly, TBS does not substantially improve diagnostic reproducibility of the cytologic diagnoses of squamous intraepithelial lesions, while providing considerably less information to the clinician than the four-grade dysplasia/CIS terminology, thus eliminating the opportunity of choosing a different procedure for the diagnosis of dysplasia media, which is of utmost importance in the population of young nulliparae.
Abstract (croatian)
Cilj rada je bio usporediti interobserver varijabilnost za The Bethesda System (TBS) i World Health Organization (WHO) klasifikaciju skvamoznih intraepitelnih lezija cerviksa uterusa. Set od 1000 konvencionalnih Papa razmaza (156 pozitivnih i 884 negativnih) »na slijepo« su pregledala 3 citologa i jedan citotehničar. Stupanj slaganja je izražen kappa statistikom pomoću programa za računanje interobserver varijacija i asocijacija »Agree« (Svanholm i Jergensen, 1989.). Weighted je određen za svaku citološku dijagnozu unutar klasifikacije, kao i za klasifikacije u cijelosti. Za svaku citološku dijagnozu je određena povezanost, odnosno razgraničenost s drugim dijagnozama u obliku uvjetne vjerojatnosti (Pj). Kod WHO klasifikacije su slabo reproducibilne dijagnoze dysplasia media (=0,114) i dysplasia gravis (=0,259), prilično dobro je reproducibilna dijagnoza dysplasia levis (=0,639), a odlično je reproducibilna dijagnoza carcinoma in situ (=0,762). Za klasifikaciju u cijelosti je 0,741. Kod TBS klasifikacije LSIL je prilično dobro reproducibilna dijagnoza (=0,542), dok je HSIL odlično reproducibilna dijagnoza (=0,763). Za klasifikaciju u cijelosti je 0,699. Dysplasia media (P=0,121) i dysplasia gravis (Pj=0,274) su morfološki slabo definirane dijagnoze, carcinoma in situ (Pj=0,777) i dysplasia levis (Pj=0,651) su dobro definirane dijagnoze. LSIL (Pj=0,587) je morfološki srednje definirana dijagnoza, dok je HSIL (Pj=0,789) dobro definirana dijagnoza.TBS ne popravlja bitno dijagnostičku reproducibilnost citoloških dijagnoza za skvamozne intraepitelne lezije, a kliničaru daje znatno manje informacija nego četverodijelna dysplasia / CIS terminologija i time oduzima mogućnost različitog postupka za dijagnozu dysplasia media što je osobito važno za populaciju mladih nulipara i trudnica.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 30, no. 1, pp. 137-142
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:754555
Publication2006
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=13597
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-19 10:26:39