prikaz prve stranice dokumenta Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study
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Scientific paper - Original scientific paper
Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study
Croatian medical journal, 56 (2015), 4; 334-343. https://doi.org/10.3325/cmj.2015.56.334
Perisa, Vlatka; Zibar, Lada; Sincic-Petricevic, Jasminka; Knezovic, Ana; Perisa, Igor; Barbic, Jerko

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Perisa, V., Zibar, L., Sincic Petricevic, J., Knezovic, A., Perisa, I. & Barbic, J. (2015). Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study. Croatian medical journal, 56. (4), 334-343. doi: 10.3325/cmj.2015.56.334

Perisa, Vlatka, et al. "Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study." Croatian medical journal, vol. 56, no. 4, 2015, pp. 334-343. https://doi.org/10.3325/cmj.2015.56.334

Perisa, Vlatka, Lada Zibar, Jasminka Sincic Petricevic, Ana Knezovic, Igor Perisa and Jerko Barbic. "Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study." Croatian medical journal 56, no. 4 (2015): 334-343. https://doi.org/10.3325/cmj.2015.56.334

Perisa, V., et al. (2015) 'Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study', Croatian medical journal, 56(4), pp. 334-343. doi: 10.3325/cmj.2015.56.334

Perisa V, Zibar L, Sincic Petricevic J, Knezovic A, Perisa I, Barbic J. Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study. Croatian medical journal [Internet]. 2015 [cited 2024 November 17];56(4):334-343. doi: 10.3325/cmj.2015.56.334

V. Perisa, L. Zibar, J. Sincic Petricevic, A. Knezovic, I. Perisa and J. Barbic, "Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study", Croatian medical journal, vol. 56, no. 4, pp. 334-343, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:474625. [Accessed: 17 November 2024]

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Metadata
Title (english)Red Blood Cell Distribution Width as a Simple Negative Prognostic Factor in Patients With Diffuse Large B-cell Lymphoma: a Retrospective Study
AuthorVlatka Perisa
MBZ: 363604
AuthorLada Zibar
MBZ: 254864
AuthorJasminka Sincic-Petricevic
AuthorAna Knezovic
MBZ: 320641
AuthorIgor Perisa
AuthorJerko Barbic
MBZ: 258420
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Aim to determine the prognostic value of baseline red blood cell distribution width (RDW) in diffuse large B cell lymphoma (DLBCL) patients. Methods: data from 81 DLBCL patients diagnosed from 2006 to 2013 at the University Hospital Center Osijek, Osijek, Croatia, were reviewed. We evaluated disease outcome, overall survival (OS) and event-free survival (EFS), an demographic, clinical and laboratory factors affecting outcome. Univariate analysis and Cox regression analysis were used. Results: median age of patients was 64 years, 29 were men (35.8%). Higher RDW levels (%) were found in patients with advanced Ann Arbor clinical stage (14.94 ± 1.82 vs 13.55 ± 1.54, P = 0.001) and in those with poor response to therapy (14.94 ± 1.82 vs 13.55 ± 1.54, P = 0.001). Patients with RDW>15% (cut-off was calculated by receiver operating characteristics) had significantly worse OS (median [range], 33 months [20-46] vs 74 months [65-82], P < 0.001) and EFS (27 months [15-40] vs 68 months [59-77], P < 0.001). Cox regression analysis showed that RDW>15% was an independent prognostic factor for OS (HR 3.654, 95% CI 1.128-11.836) and EFS (HR 2.611, 95% CI 1.012-6-739). Conclusion: high baseline RDW is an independent prognostic marker of poor outcome in patients with DLBCL. RDW could be an easily available and inexpensive marker for the risk stratification in patients with DLBCL.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatian medical journal
Numberingvol. 56, no. 4, pp. 334-343
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2015.56.334
URN:NBNurn:nbn:hr:239:474625
Publication2015
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=222900
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-09-16 12:25:31