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Scientific paper - Original scientific paper
Dynamics of Exhaled Breath Temperature after Smoking a Cigarette and its Association with Lung Function Changes Predictive of COPD Risk in Smokers: a Cross-sectional Study
Arhiv za higijenu rada i toksikologiju, 70 (2019), 2; 123-129. https://doi.org/10.2478/aiht-2019-70-3211
Huljev Šipoš, Ivana; Labor, Slavica; Jurić, Iva; Plavec, Davor; Vlahoviček, Kristian; Bogović, Siniša; Pavkov Vukelić, Justinija; Labor, Marina

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Huljev Šipoš, I., Labor, S., Jurić, I., Plavec, D., Vlahoviček, K., Bogović, S. ... Labor, M. (2019). Dynamics of Exhaled Breath Temperature after Smoking a Cigarette and its Association with Lung Function Changes Predictive of COPD Risk in Smokers: a Cross-sectional Study. Arhiv za higijenu rada i toksikologiju, 70. (2), 123-129. doi: 10.2478/aiht-2019-70-3211

Huljev Šipoš, Ivana, et al. "Dynamics of Exhaled Breath Temperature after Smoking a Cigarette and its Association with Lung Function Changes Predictive of COPD Risk in Smokers: a Cross-sectional Study." Arhiv za higijenu rada i toksikologiju, vol. 70, no. 2, 2019, pp. 123-129. https://doi.org/10.2478/aiht-2019-70-3211

Huljev Šipoš, Ivana, Slavica Labor, Iva Jurić, Davor Plavec, Kristian Vlahoviček, Siniša Bogović, Justinija Pavkov Vukelić and Marina Labor. "Dynamics of Exhaled Breath Temperature after Smoking a Cigarette and its Association with Lung Function Changes Predictive of COPD Risk in Smokers: a Cross-sectional Study." Arhiv za higijenu rada i toksikologiju 70, no. 2 (2019): 123-129. https://doi.org/10.2478/aiht-2019-70-3211

Huljev Šipoš, I., et al. (2019) 'Dynamics of Exhaled Breath Temperature after Smoking a Cigarette and its Association with Lung Function Changes Predictive of COPD Risk in Smokers: a Cross-sectional Study', Arhiv za higijenu rada i toksikologiju, 70(2), pp. 123-129. doi: 10.2478/aiht-2019-70-3211

Huljev Šipoš I, Labor S, Jurić I, Plavec D, Vlahoviček K, Bogović S, and sur.. Dynamics of Exhaled Breath Temperature after Smoking a Cigarette and its Association with Lung Function Changes Predictive of COPD Risk in Smokers: a Cross-sectional Study. Arhiv za higijenu rada i toksikologiju [Internet]. 2019 [cited 2024 December 12];70(2):123-129. doi: 10.2478/aiht-2019-70-3211

I. Huljev Šipoš, et al., "Dynamics of Exhaled Breath Temperature after Smoking a Cigarette and its Association with Lung Function Changes Predictive of COPD Risk in Smokers: a Cross-sectional Study", Arhiv za higijenu rada i toksikologiju, vol. 70, no. 2, pp. 123-129, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:248215. [Accessed: 12 December 2024]

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Title (english)Dynamics of Exhaled Breath Temperature after Smoking a Cigarette and its Association with Lung Function Changes Predictive of COPD Risk in Smokers: a Cross-sectional Study
Title (croatian)Presječna studija dinamike temperature izdaha nakon popušene cigarete i njezina povezanost s promjenama plućne funkcije u pušača prediktivnima za rizik od KOPB-a
AuthorIvana Huljev Šipoš
AuthorSlavica Labor
MBZ: 330076
AuthorIva Jurić
AuthorDavor Plavec
MBZ: 159962
AuthorKristian Vlahoviček
MBZ: 216094
AuthorSiniša Bogović
MBZ: 199222
AuthorJustinija Pavkov Vukelić
AuthorMarina Labor
MBZ: 357633
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Exhaled breath temperature (EBT) is a biomarker of inflammation and vascularity of the airways already shown to predict incident COPD. This cross-sectional study was aimed to assess the potential of EBT in identifying “healthy” smokers susceptible to cigarette smoke toxicity of the airways and to the risk of developing COPD by analysing the dynamics of EBT after smoking a cigarette and its associations with their demographics (age, smoking burden) and lung function. The study included 55 current smokers of both sexes, 29–62 years of age, with median smoking exposure of 15 (10–71.8) pack-years. EBT was measured at baseline and 5, 15, 30, 45, and 60 min after smoking a single cigarette. Lung function was measured with spirometry followed by a bronchodilator test. To compare changes in EBT between repeated measurements we used the analysis of variance and the area under the curve (EBTAUC) as a dependent variable. Multivariate regression analysis was used to look for associations with patient characteristics and lung function in particular. The average (±SD) baseline EBT was 33.42±1.50 °C. The highest significant increase to 33.84 (1.25) °C was recorded 5 min after the cigarette was smoked (p=0.003), and it took one hour for it to return to the baseline. EBTAUC showed significant repeatability (ICC=0.85, p<0.001) and was significantly associated with age, body mass index, number of cigarettes smoked a day, baseline EBT, and baseline FEF75 (R2=0.39, p<0.001 for the model). Our results suggest that EBT after smoking a single cigarette could be used as early risk predictor of changes associated with chronic cigarette smoke exposure.
Abstract (croatian)
Temperatura izdaha (EBT) biomarker je upale i vaskularizacije dišnih putova za koji je utvrđeno da može predvidjeti nastanak KOPB-a. Cilj ove presječne studije bio je procijeniti potencijal EBT-a u identifikaciji “zdravih” pušača čiji su dišni putovi osjetljivi na toksični učinak duhanskoga dima uz rizik od nastanka KOPB-a. Taj se cilj planirao postići utvrđivanjem povezanosti dinamike EBT-a nakon popušene cigarete s demografskim karakteristikama (dob, spol, pušačka navika) i plućnom funkcijom ispitanika. U ispitivanje je bilo uključeno 55 aktivnih pušača obaju spolova u dobi od 29 do 62 godine, čiji je medijan izloženosti duhanskom dimu bio 15 (10 – 71,8) pušačkih godina (pack-years). EBT je mjeren na početku te 5, 15, 30, 45 i 60 minuta nakon popušene cigarete. Plućnu funkciju mjerili smo spirometrijski, uz susljedni bronhodilatacijski test. Za analizu dinamike EBT-a koristili smo se analizom varijance te smo izračunali površinu ispod krivulje u odnosu na početno mjerenje (EBTAUC) te EBTAUC upotrijebili kao zavisnu varijablu. Multivarijatna regresijska analiza korištena je za utvrđivanje povezanosti EBTAUC s karakteristikama ispitanika, posebice s plućnom funkcijom. Prosječni (±SD) izmjereni početni EBT bio je 33,42±1,50 °C, a najveće značajno izmjereno povećanje zabilježeno je 5 minuta nakon popušene cigarete (33,84 (1,25) °C, p=0,003). Bilo je potrebno 60 minuta kako bi se EBT vratio na početnu vrijednost. Utvrđena je značajna ponovljivost EBTAUC (ICC=0,85, p<0,001). Ispitivanjem je utvrđeno je da je EBTAUC značajno nezavisno povezan s dobi, indeksom tjelesne mase, brojem popušenih cigareta dnevno, početnim EBT-om te s početnim FEF75 (R2=0,39, p<0,001 za model). Rezultati ove studije sugeriraju da EBT nakon popušene cigarete može biti koristan kao rani prediktor rizika od promjena koje su povezane s kroničnom izloženosti duhanskom dimu.
Keywords (english)
Keywords (croatian)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArhiv za higijenu rada i toksikologiju
Numberingvol. 70, no. 2, pp. 123-129
p-ISSN0004-1254
e-ISSN1848-6312
DOIhttps://doi.org/10.2478/aiht-2019-70-3211
URN:NBNurn:nbn:hr:239:248215
Publication2019
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=322573
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) icon
Created on2019-09-27 11:46:03