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Krioglobulinemični vaskulitis kao manifestacija paraneoplastičkog sindroma - prikaz bolesnika
Reumatizam, 62 (2015), 1; 27-30. urn:nbn:hr:239:976916
Milas-Ahić, Jasminka; Prus, Višnja; Šustić, Nela; Višević, Roberta; Kovačević, Ivana; Kardum, Željka

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Milas Ahić, J., Prus, V., Šustić, N., Višević, R., Kovačević, I. & Kardum, Ž. (2015). Krioglobulinemični vaskulitis kao manifestacija paraneoplastičkog sindroma - prikaz bolesnika. Reumatizam, 62. (1), 27-30. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:976916

Milas Ahić, Jasminka, et al. "Krioglobulinemični vaskulitis kao manifestacija paraneoplastičkog sindroma - prikaz bolesnika." Reumatizam, vol. 62, no. 1, 2015, pp. 27-30. https://urn.nsk.hr/urn:nbn:hr:239:976916

Milas Ahić, Jasminka, Višnja Prus, Nela Šustić, Roberta Višević, Ivana Kovačević and Željka Kardum. "Krioglobulinemični vaskulitis kao manifestacija paraneoplastičkog sindroma - prikaz bolesnika." Reumatizam 62, no. 1 (2015): 27-30. https://urn.nsk.hr/urn:nbn:hr:239:976916

Milas Ahić, J., et al. (2015) 'Krioglobulinemični vaskulitis kao manifestacija paraneoplastičkog sindroma - prikaz bolesnika', Reumatizam, 62(1), pp. 27-30. Available at: https://urn.nsk.hr/urn:nbn:hr:239:976916 (Accessed 28 October 2024)

Milas Ahić J, Prus V, Šustić N, Višević R, Kovačević I, Kardum Ž. Krioglobulinemični vaskulitis kao manifestacija paraneoplastičkog sindroma - prikaz bolesnika. Reumatizam [Internet]. 2015 [cited 2024 October 28];62(1):27-30. Available at: https://urn.nsk.hr/urn:nbn:hr:239:976916

J. Milas Ahić, V. Prus, N. Šustić, R. Višević, I. Kovačević and Ž. Kardum, "Krioglobulinemični vaskulitis kao manifestacija paraneoplastičkog sindroma - prikaz bolesnika", Reumatizam, vol. 62, no. 1, pp. 27-30, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:976916. [Accessed: 28 October 2024]

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Metadata
Title (croatian)Krioglobulinemični vaskulitis kao manifestacija paraneoplastičkog sindroma - prikaz bolesnika
Title (english)Cryoglobulinemic vasculitis as a manifestation of paraneoplastic syndrome – a case report
AuthorJasminka Milas-Ahić
MBZ: 288280
AuthorVišnja Prus
MBZ: 333013
AuthorNela Šustić
AuthorRoberta Višević
AuthorIvana Kovačević
MBZ: 307014
AuthorŽeljka Kardum
Author's institution(Clinical hospital center Osijek)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (croatian)
Krioglobulinemija predstavlja prisutnost cirkulirajućih krioglobulina u serumu koji mogu dovesti do organskih oštećenja te sistemskog odgovora karakteriziranog umorom, artralgijama, purpurom, neuropatijom i glomerulonefritisom. Bolest uglavnom zahvaća male i srednje krvne žile i uzrokuje vaskulitis zbog stvaranja imunokompleksa koja sadrže krioglobuline. Miješane krioglobulinemije (tip I. i II.) najčešće su povezane s infekcijama, naročito hepatitisom C (HCV), ali se mogu javljati u sklopu limfoproliferativnih bolesti te autoimunih bolesti. Prikazali smo 75-godišnjeg bolesnika s akrocijanozom i nekrozom distalnih falangi 2. i 4. prsta lijeve šake te purpuroznim promjenama donjih ekstremiteta. Od 2001. bolesnik je liječen po hematologu zbog non-Hodgkinova limfoma želuca (MALT), a od 2002. godine kontrolira se zbog primarnog Sjogrenova sindroma. Učinjenom opsežnom obradom nađena je krioglobulinemija tip II., ali bez dokaza HCV-infekcije ili relapsa limfoproliferativne bolesti. Naknadnom obradom dokazan je slabo diferencirani adenokarcinom prostate i započeto liječenje antiandrogenom. Oko godinu dana nakon pojave simptoma akrocijanoze i digitalne nekroze kontrolnom endoskopskom obradom dokazan je i adenokarcinom želuca, bez tumorskih presadnica, te je provedeno kirurško liječenje. Međutim, postoperativno se razvija kliničko pogoršanje uz pojavu novih digitalnih nekroza na rukama te ubrzo dolazi do smrtnog ishoda pod slikom višesustavnog organskog zatajenja. Povezanost krioglobulinemije i solidnih tumora rijetko je opisana u literaturi, stoga je od izuzetnog značenja detaljna dijagnostička obrada radi što ranijeg otkrivanja osnovne bolesti.
Abstract (english)
Cryoglobulinemia refers to the presence of circulating cryoglobulins in the serum which may lead to organ damage and systemic response characterized by fatigue, arthralgias, purpura, glomerulonephritis and neuropathy. Th e disease mainly aff ects small and medium-sized blood vessels and causes vasculitis due to cryoglobulin-containing immune complexes. Mixed cryoglobulinemia (type I and II) are most oft en associated with infections, especially hepatitis C virus (HCV), but may occur as part of lymphoproliferative and autoimmune diseases. We present a 75 -yearold male patient with acrocyanosis and digital necrosis of the left hand and purpura of the lower extremities. Since 2001 the patient was treated for Non- Hodgkin’s lymphoma of the stomach (MALT) and since 2002 for Sjogren’s syndrome. Extensive diagnostic procedures revealed cryoglobulinemia type II, but without evidence of HCV infection or relapse of lymphoproliferative disorder. Furthermore, poorly diff erentiated prostate adenocarcinoma was diagnosed and antiandrogen treatment was initiated. One year aft er the onset of symptoms acrocyanosis and digital necrosis, gastric adenocarcinoma was diagnosed, without metastatic disease, and surgical treatment was performed. However, postoperatively recurrence of new digital necrosis of the hands occurred along with clinical deterioration and multiple organ failure leading to lethal outcome. Association of cryoglobulinemia and solid tumors is rarely described in the literature, so it is very important to perform comprehensive diagnostic evaluation and detect potential underlying disease as soon as possible.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeOther - Review
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleReumatizam
Numberingvol. 62, no. 1, pp. 27-30
p-ISSN0374-1338
e-ISSN2459-6159
URN:NBNurn:nbn:hr:239:976916
Publication2015
Document URLhttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=269398
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-06-27 09:24:12