prikaz prve stranice dokumenta Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia
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Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia
Archives of Virology, 160 (2015), 1; 297-304. https://doi.org/10.1007/s00705-014-2283-0
Perić, Magdalena; Bošnjak, Zinka; Šarkanj, Bojan; Barbić, Jerko; Antolović-Požgain, Arlen; Ružman, Nataša; Roksandić-Križan, Ivana; Vuković, Dubravka

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Perić, M., Bošnjak, Z., Šarkanj, B., Barbić, J., Antolović Požgain, A., Ružman, N. ... Vuković, D. (2015). Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia. Archives of Virology, 160. (1), 297-304. doi: 10.1007/s00705-014-2283-0

Perić, Magdalena, et al. "Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia." Archives of Virology, vol. 160, br. 1, 2015, str. 297-304. https://doi.org/10.1007/s00705-014-2283-0

Perić, Magdalena, Zinka Bošnjak, Bojan Šarkanj, Jerko Barbić, Arlen Antolović Požgain, Nataša Ružman, Ivana Roksandić Križan i Dubravka Vuković. "Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia." Archives of Virology 160, br. 1 (2015): 297-304. https://doi.org/10.1007/s00705-014-2283-0

Perić, M., et al. (2015) 'Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia', Archives of Virology, 160(1), str. 297-304. doi: 10.1007/s00705-014-2283-0

Perić M, Bošnjak Z, Šarkanj B, Barbić J, Antolović Požgain A, Ružman N, i sur.. Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia. Archives of Virology [Internet]. 2015. [pristupljeno 25.04.2024.];160(1):297-304. doi: 10.1007/s00705-014-2283-0

M. Perić, et al., "Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia", Archives of Virology, vol. 160, br. 1, str. 297-304, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:131646. [Citirano: 25.04.2024.]

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Podaci o radu
Naslov (engleski)Polymorphisms of Toll-like Receptors 2 and 4 in Chronically Infected Hepatitis C Patients from North-east Croatia
AutorMagdalena Perić
MBZ: 339363
AutorZinka Bošnjak
MBZ: 339352
AutorBojan Šarkanj
MBZ: 300455
AutorJerko Barbić
MBZ: 258420
AutorArlen Antolović-Požgain
MBZ: 338395
AutorNataša Ružman
AutorIvana Roksandić-Križan
MBZ: 315592
AutorDubravka Vuković
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Infektologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Chronic infection with hepatitis C virus (HCV) is caused by an inadequate immune response. Experimental data suggest that the impaired activation of Toll-like receptors (TLRs) 2 and 4 contributes to chronic infection. We assessed the distribution of three single-nucleotide polymorphisms (SNPs) in the TLR2 (Arg753Gln) and TLR4 (Asp299Gly/Thr399Ile) genes in individuals from north-east Croatia and their effect on the outcome of antiviral therapy. The study consisted of 60 chronically infected patients and 40 healthy subjects. TLR polymorphisms were determined by the PCR-based melting curve analysis. HCV genotyping was performed using the Linear Array Hepatitis C Virus Genotyping Test. Thirty-three patients were treated with standard interferon and ribavirin therapy, and their viral load was evaluated at weeks 28 and 53 after the beginning of therapy. The majority of chronic infections were caused by genotype 1 (77%), followed by genotypes 3 (15%) and 4 (7%). Patients with genotype 1 had higher viral loads than patients infected with other genotypes (P = 0.0428). Healthy individuals and patients with chronic infection had similar frequencies of TLR2-Arg753Gln and TLR4-Asp299Gly/Thr399Ile SNPs. Heterozygous and homozygous TLR4-Asp299Gly/Thr399Ile polymorphisms correlated with higher viral loads and delayed responses to antiviral therapy. We have provided the first evidence that TLR4 polymorphisms influence the success of antiviral therapy in our region. This suggests that therapeutic strategies should be adjusted not only according to HCV genotype but also to individual TLR polymorphism(s).
Ključne riječi (engleski)
Jezikhrvatski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaArchives of Virology
Brojčani podacivol. 160, br. 1, str. 297-304
p-ISSN0304-8608
e-ISSN1432-8798
DOIhttps://doi.org/10.1007/s00705-014-2283-0
URN:NBNurn:nbn:hr:239:131646
Datum objave publikacije2015
URL dokumentahttps://link.springer.com/article/10.1007%2Fs00705-014-2283-0
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-10-31 09:07:58