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Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome
International Journal of Environmental Research and Public Health, 15 (2018), 7; 1-7. https://doi.org/10.3390/ijerph15071486
Vukšić Polić, Melita; Miškulin, Maja; Smolić, Martina; Kralik, Kristina; Miškulin, Ivan; Cigrovski Berković, Maja; Bilić Ćurčić, Ines

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Vukšić Polić, M., Miškulin, M., Smolić, M., Kralik, K., Miškulin, I., Cigrovski Berković, M. i Bilić Ćurčić, I. (2018). Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome. International Journal of Environmental Research and Public Health, 15. (7), 1-7. doi: 10.3390/ijerph15071486

Vukšić Polić, Melita, et al. "Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome." International Journal of Environmental Research and Public Health, vol. 15, br. 7, 2018, str. 1-7. https://doi.org/10.3390/ijerph15071486

Vukšić Polić, Melita, Maja Miškulin, Martina Smolić, Kristina Kralik, Ivan Miškulin, Maja Cigrovski Berković i Ines Bilić Ćurčić. "Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome." International Journal of Environmental Research and Public Health 15, br. 7 (2018): 1-7. https://doi.org/10.3390/ijerph15071486

Vukšić Polić, M., et al. (2018) 'Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome', International Journal of Environmental Research and Public Health, 15(7), str. 1-7. doi: 10.3390/ijerph15071486

Vukšić Polić M, Miškulin M, Smolić M, Kralik K, Miškulin I, Cigrovski Berković M, i sur.. Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome. International Journal of Environmental Research and Public Health [Internet]. 2018. [pristupljeno 20.04.2024.];15(7):1-7. doi: 10.3390/ijerph15071486

M. Vukšić Polić, et al., "Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome", International Journal of Environmental Research and Public Health, vol. 15, br. 7, str. 1-7, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:395050. [Citirano: 20.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:239:395050
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Podaci o radu
Naslov (engleski)Psoriasis Severity-a risk Factor of Insulin Resistance Independent of Metabolic Syndrome
AutorMelita Vukšić Polić
MBZ: 316624
AutorMaja Miškulin
MBZ: 290921
AutorMartina Smolić
MBZ: 292155
AutorKristina Kralik
AutorIvan Miškulin
MBZ: 350925
AutorMaja Cigrovski Berković
MBZ: 314071
AutorInes Bilić Ćurčić
MBZ: 268184
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanova(Klinički bolnički centar Sestre milosrdnice)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
BACKGROUND: It is still debatable whether psoriasis increases cardiovascular risk indirectly since it is associated with metabolic syndrome or is an independent cardiovascular risk factor. The aim of this study was to evaluate psoriasis severity as an independent predictor of insulin resistance (IR) irrespective of the presence of metabolic syndrome (MetS). METHODS: This was a case control study including 128 patients stratified into two groups: patients with psoriasis and metabolic syndrome vs. patients with psoriasis and no metabolic syndrome. MetS was diagnosed according to ATP III criteria with homeostatic model assessment of insulin resistance (HOMA-IR), as well as a homeostatic model assessment of beta cell function (HOMA-β) were calculated. RESULTS: Compared to subjects without metabolic syndrome, patients with metabolic syndrome had a significantly higher Psoriasis Area Severity Index (PASI) values (p < 0.001). The strongest correlation was established for HOMA-IR and the PASI index (p < 0.001), even after adjustment for body mass index (BMI) in regression analysis model. In patients without MetS and severe forms of disease, the HOMA-IR and HOMA-β values were significantly higher compared to mild forms of disease (p < 0.001 for all) while in subjects with MetS no difference was established for HOMA-IR or HOMA-β based on disease severity. CONCLUSIONS: Psoriasis severity is an independent risk factor of HOMA-IR, the strongest association being present in the non-MetS group, who still had preserved beta cell function suggesting direct promotion of atherosclerosis via insulin resistance depending on the disease severity, but irrespective of the presence of metabolic syndrome.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Environmental Research and Public Health
Brojčani podacivol. 15, br. 7, str. 1-7
e-ISSN1660-4601
DOIhttps://doi.org/10.3390/ijerph15071486
URN:NBNurn:nbn:hr:239:395050
Datum objave publikacije2018
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069377/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-01-17 14:03:51