prikaz prve stranice dokumenta Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies
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Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies
Medical Science Monitor, 24 (2018); 5084-5092. https://doi.org/10.12659/MSM.909172
Boban, Marko; Peša, Vladimir; Peršić, Viktor; Žulj, Marinko; Malčić, Ivan; Beck, Natko; Včev, Aleksandar

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Boban, M., Peša, V., Peršić, V., Žulj, M., Malčić, I., Beck, N. i Včev, A. (2018). Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies. Medical Science Monitor, 24., 5084-5092. doi: 10.12659/MSM.909172

Boban, Marko, et al. "Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies." Medical Science Monitor, vol. 24, 2018, str. 5084-5092. https://doi.org/10.12659/MSM.909172

Boban, Marko, Vladimir Peša, Viktor Peršić, Marinko Žulj, Ivan Malčić, Natko Beck i Aleksandar Včev. "Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies." Medical Science Monitor 24 (2018): 5084-5092. https://doi.org/10.12659/MSM.909172

Boban, M., et al. (2018) 'Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies', Medical Science Monitor, 24, str. 5084-5092. doi: 10.12659/MSM.909172

Boban M, Peša V, Peršić V, Žulj M, Malčić I, Beck N, i sur.. Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies. Medical Science Monitor [Internet]. 2018. [pristupljeno 09.12.2024.];24:5084-5092. doi: 10.12659/MSM.909172

M. Boban, et al., "Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies", Medical Science Monitor, vol. 24, str. 5084-5092, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:712276. [Citirano: 09.12.2024.]

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Podaci o radu
Naslov (engleski)Overlapping Phenotypes and Degree of Ventricular Dilatation are Associated with Severity of Systolic Impairment and Late Gadolinium Enhancement in Non-Ischemic Cardiomyopathies
AutorMarko Boban
MBZ: 340711
AutorVladimir Peša
AutorViktor Peršić
MBZ: 303361
AutorMarinko Žulj
AutorIvan Malčić
MBZ: 115261
AutorNatko Beck
AutorAleksandar Včev
MBZ: 141721
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
Background: Dilatation and other infrastructural rearrangements of the left ventricle are connected with poor prognosis. The aim of our study was to analyze the overlapping phenotypes and dilatation of the ventricle on impairment of systolic function and existence of late gadolinium enhancement (LGE). Material/Methods: Consecutive sample of cases with dilated left ventricle due to non-ischemic cardiomyopathy and healthy controls were included from our cardiac magnetic resonance imaging (CMR) database for a period of 3 years (n=1551 exams). Results: The study included 127 patients; 30 (23.6%) with dilated cardiomyopathy (DCM); 30 (23.6%) with left ventricular non-compaction (LVNC); 13 (10.2%) with hypertrophic cardiomyopathy (HCM), and 50 (39.4%) controls. Overlapping phenotypes were found in 48 (37.8%) of the studied cases. Odds for impairment of systolic function in connection with overlapping phenotypes were estimated at 7.8 (95%-CI: 3.4–17.6), (p<0.001). There were significant differences in geometric parameters for patients with overlapping phenotypes vs. controls, as follows: left ventricle end-diastolic dimension(LVEDD)=6.6±0.8 vs. 5.6±1.0 cm (p<0.001); left ventricular ejection fraction (LVEF)=39.3±14.0 vs. 52.1±16.1 (p<0.001); and existence of LGE 36 (75.0%) vs. 21 (26.6%), (p<0.001), respectively. Overlapping phenotypes correlated with LVEDD (Spearman’s-Rho-CC)=0.521, p<0.001; LVEF (Rho- CC)=–0.447, p<0.001 and LGE (Rho-CC)=0.472, p<0.001. Conclusions: This study found there are many patients with overlapping phenotypes among NICMPs with dilated left ventricles. Overlapping phenotype was associated with greater LVEDD, lesser systolic function, and commonly existing LGE, which all impose increased cardiovascular risk. Linear midventricular LGE stripe was the most powerfully connected with loss of systolic function.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedical Science Monitor
Brojčani podacivol. 24, str. 5084-5092
p-ISSN1234-1010
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.909172
URN:NBNurn:nbn:hr:239:712276
Datum objave publikacije2018
URL dokumentahttp://europepmc.org/abstract/MED/30032158
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-10-23 11:50:34