prikaz prve stranice dokumenta Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids
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Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids
Diabetes and Vascular Disease Research, 12 (2015), 1; 33-45. https://doi.org/10.1177/1479164114553424
Kibel, Aleksandar; Novak, Sanja; ĆosiĆ, Anita; Mihaljević, Zrinka; Falck, John R; Drenjančević, Ines

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Kibel, A., Novak, S., ĆosiĆ, A., Mihaljević, Z., Falck, J. R. i Drenjančević, I. (2015). Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids. Diabetes and Vascular Disease Research, 12. (1), 33-45. doi: 10.1177/1479164114553424

Kibel, Aleksandar, et al. "Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids." Diabetes and Vascular Disease Research, vol. 12, br. 1, 2015, str. 33-45. https://doi.org/10.1177/1479164114553424

Kibel, Aleksandar, Sanja Novak, Anita ĆosiĆ, Zrinka Mihaljević, John R Falck i Ines Drenjančević. "Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids." Diabetes and Vascular Disease Research 12, br. 1 (2015): 33-45. https://doi.org/10.1177/1479164114553424

Kibel, A., et al. (2015) 'Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids', Diabetes and Vascular Disease Research, 12(1), str. 33-45. doi: 10.1177/1479164114553424

Kibel A, Novak S, ĆosiĆ A, Mihaljević Z, Falck JR, Drenjančević I. Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids. Diabetes and Vascular Disease Research [Internet]. 2015. [pristupljeno 13.12.2024.];12(1):33-45. doi: 10.1177/1479164114553424

A. Kibel, S. Novak, A. ĆosiĆ, Z. Mihaljević, J. R. Falck i I. Drenjančević, "Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids", Diabetes and Vascular Disease Research, vol. 12, br. 1, str. 33-45, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:597138. [Citirano: 13.12.2024.]

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Podaci o radu
Naslov (engleski)Hyperbaric Oxygenation Modulates Vascular Reactivity to Angiotensin-(1-7) in Diabetic Rats: Potential Role of Epoxyeicosatrienoic Acids
AutorAleksandar Kibel
MBZ: 344370
AutorSanja Novak
MBZ: 326355
AutorAnita ĆosiĆ
AutorZrinka Mihaljević
MBZ: 324952
AutorJohn R Falck
AutorInes Drenjančević
MBZ: 209603
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička biokemija
Sažetak (engleski)
Previously, a facilitating effect of hyperbaric oxygenation (HBO₂) on aortic ring responses to angiotensin-(1-7) in healthy rats was reported, with epoxyeicosatrienoic acids (EETs) possibly playing an important role. The aim of this study was to assess whether HBO₂ exerts similar effects in diabetic rats and to further explore the role of specific cytochrome P450 (CYP) enzymes in changes induced by HBO₂. Aortic relaxation to angiotensin-(1-7) was significantly higher in HBO₂ diabetic rats compared to control diabetic rats, while HBO₂ had no effect on angiotensin II contraction. N-methylsulphonyl-6-(2 propargyloxyphenyl /hexanamide inhibited the facilitation of angiotensin-(1-7) responses in HBO₂ rats, suggesting an important role of EETs in this modulation. mRNA expression of CYP2J3 and protein expression of CYP2C11 were significantly upregulated in HBO₂ diabetic rats, whereas CYP4A1, CYP4A2 and CYP4A3 mRNA and CYP2J3 protein expression was similar between groups. Mean arterial pressure, ferric reducing ability of plasma and Thiobarbituric Acid Reactive Substances levels and serum angiotensin-(1-7) concentrations were not significantly changed.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaDiabetes and Vascular Disease Research
Brojčani podacivol. 12, br. 1, str. 33-45
p-ISSN1479-1641
e-ISSN1752-8984
DOIhttps://doi.org/10.1177/1479164114553424
URN:NBNurn:nbn:hr:239:597138
Datum objave publikacije2015
URL dokumentahttps://journals.sagepub.com/doi/10.1177/1479164114553424
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno 4.0 međunarodna (CC BY-NC 4.0)
Datum i vrijeme pohrane2019-10-29 08:10:32