prikaz prve stranice dokumenta The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women
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The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women
Journal of Maternal-Fetal and Neonatal Medicine, 29 (2015), 2; 264-269. https://doi.org/10.3109/14767058.2014.998189
Lenz, Bahrija; Samardžija, Marina; Drenjančević, Domagoj; Zibar, Davor; Samardžija, Marko; Milostić-Srb, Andrea

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Lenz, B., Samardžija, M., Drenjančević, D., Zibar, D., Samardžija, M. i Milostić Srb, A. (2015). The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women. Journal of Maternal-Fetal and Neonatal Medicine, 29. (2), 264-269. doi: 10.3109/14767058.2014.998189

Lenz, Bahrija, et al. "The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women." Journal of Maternal-Fetal and Neonatal Medicine, vol. 29, br. 2, 2015, str. 264-269. https://doi.org/10.3109/14767058.2014.998189

Lenz, Bahrija, Marina Samardžija, Domagoj Drenjančević, Davor Zibar, Marko Samardžija i Andrea Milostić Srb. "The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women." Journal of Maternal-Fetal and Neonatal Medicine 29, br. 2 (2015): 264-269. https://doi.org/10.3109/14767058.2014.998189

Lenz, B., et al. (2015) 'The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women', Journal of Maternal-Fetal and Neonatal Medicine, 29(2), str. 264-269. doi: 10.3109/14767058.2014.998189

Lenz B, Samardžija M, Drenjančević D, Zibar D, Samardžija M, Milostić Srb A. The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women. Journal of Maternal-Fetal and Neonatal Medicine [Internet]. 2015. [pristupljeno 26.10.2024.];29(2):264-269. doi: 10.3109/14767058.2014.998189

B. Lenz, M. Samardžija, D. Drenjančević, D. Zibar, M. Samardžija i A. Milostić Srb, "The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women", Journal of Maternal-Fetal and Neonatal Medicine, vol. 29, br. 2, str. 264-269, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:836849. [Citirano: 26.10.2024.]

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Podaci o radu
Naslov (engleski)The Investigation of Hereditary and Acquired Thrombophilia risk Factors in the Development of Complications in Pregnancy in Croatian Women
AutorBahrija Lenz
MBZ: 261316
AutorMarina Samardžija
MBZ: 269264
AutorDomagoj Drenjančević
MBZ: 297300
AutorDavor Zibar
AutorMarko Samardžija
AutorAndrea Milostić-Srb
MBZ: 239325
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Sažetak (engleski)
OBJECTIVES: To investigate the genetic and acquired thrombophilic risk factors in pregnancy-associated complications and venous thromboembolism (VTE) and evaluate the association between particular thrombophilic risk factors and thromboembolic complications. METHODS: In this study, pregnant women with pregnancy complications and VTE (N = 101) were the study group, and the control group were women with normal pregnancy (N = 102). All women underwent testing for factor V Leiden mutation (FVL), mutation of the coagulation factors II (FII20210), methylenetetrahydrofolate reductase (MTHFR), plasminogen activator inhibitor-1, antithrombin III (ATIII), protein C (PC) and protein S, lupus anticoagulant (LAC) antibodies, anticardiolipin antibodies and anti-beta-2-glycoprotein-1. RESULTS: In this study group, mutations of the FVL was 15.8% (16/101), FII20210 5.9% (6/101) and the MTHFR at locus 677 was TT in 19.8% (20/101). Deficiency of ATIII and PC were rare: 3.0% and 1.0%, respectively. LAC were significantly higher in the study group than in the control group: 32.7% versus 3.9%; p < 0.0005. Pregnant women with VTE have been more frequent for FVL (41.7%; p < 0.005), PC deficiency (25.0%; p < 0.005) and LAC (33.3%; p < 0.005). Combination of FVL and MTHFR mutation was related to the risk of recurrent fetal death and habitual abortion. CONCLUSION: The inherited and the acquired thrombophilic risk factors were found to be up to 10 times more common in the study group than in the control group.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Maternal-Fetal and Neonatal Medicine
Brojčani podacivol. 29, br. 2, str. 264-269
p-ISSN1476-7058
e-ISSN1476-4954
DOIhttps://doi.org/10.3109/14767058.2014.998189
URN:NBNurn:nbn:hr:239:836849
Datum objave publikacije2015
URL dokumentahttps://www.tandfonline.com/doi/full/10.3109/14767058.2014.998189
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 3.0 (CC BY 3.0)
Datum i vrijeme pohrane2019-10-29 13:27:22