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Cystic Fibrosis: Model of Pathogenesis Based on the Apical Membrane Potential
Medicinski glasnik, 12 (2015), 1; 1-6. urn:nbn:hr:239:215205
Kurbel, Beatrica; Rapan, Saša; Kurbel, Sven

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Kurbel, B., Rapan, S. i Kurbel, S. (2015). Cystic Fibrosis: Model of Pathogenesis Based on the Apical Membrane Potential. Medicinski glasnik, 12. (1), 1-6. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:239:215205

Kurbel, Beatrica, et al. "Cystic Fibrosis: Model of Pathogenesis Based on the Apical Membrane Potential." Medicinski glasnik, vol. 12, br. 1, 2015, str. 1-6. https://urn.nsk.hr/urn:nbn:hr:239:215205

Kurbel, Beatrica, Saša Rapan i Sven Kurbel. "Cystic Fibrosis: Model of Pathogenesis Based on the Apical Membrane Potential." Medicinski glasnik 12, br. 1 (2015): 1-6. https://urn.nsk.hr/urn:nbn:hr:239:215205

Kurbel, B., Rapan, S. i Kurbel, S. (2015) 'Cystic Fibrosis: Model of Pathogenesis Based on the Apical Membrane Potential', Medicinski glasnik, 12(1), str. 1-6. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:239:215205 (Datum pristupa: 09.12.2024.)

Kurbel B, Rapan S, Kurbel S. Cystic Fibrosis: Model of Pathogenesis Based on the Apical Membrane Potential. Medicinski glasnik [Internet]. 2015. [pristupljeno 09.12.2024.];12(1):1-6. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:215205

B. Kurbel, S. Rapan i S. Kurbel, "Cystic Fibrosis: Model of Pathogenesis Based on the Apical Membrane Potential", Medicinski glasnik, vol. 12, br. 1, str. 1-6, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:215205. [Citirano: 09.12.2024.]

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Podaci o radu
Naslov (engleski)Cystic Fibrosis: Model of Pathogenesis Based on the Apical Membrane Potential
AutorBeatrica Kurbel
MBZ: 137831
AutorSaša Rapan
MBZ: 295480
AutorSven Kurbel
MBZ: 194496
Autorova ustanova(Klinički bolnički centar Osijek)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Sažetak (engleski)
A simple model of cystic fibrosis (CF) is proposed, based on the apical membrane (ApM) potential. The ApM of epithelial cells is highly permeable to sodium and activation of CFTRs makes it permeable to chloride. Calculated ApM potentials of cells with activated cystic fibrosis transmembrane conductance regulators (CFTRs) are between the sodium and chloride Nernst values and thus allow rapid absorption of both ions in exocrine glands. In CF patients the potential is near the sodium Nernst value and thus more salt is left in the ducts. Simulation predicts that the sodium driving force increases more than 3.5 times if the ApM permeability for Cl- increases from 5-94% of the sodium permeability. In pancreatic ductal cells basolateral sodium bicarbonate cotransporters (pNBC1) allows influx of bicarbonates with sodium. Bicarbonates are exchanged for intraductal chloride by anion exchanger 1 (AE1) in the ApM. Activated CFTRs let some chloride to leak back to ducts, followed by water that dilutes ductal proteins. Replenished intraductal chloride allows more bicarbonate secretion. In CF patients, pancreatic water and bicarbonate secretion is limited by the intraductal chloride pool.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedicinski glasnik
Brojčani podacivol. 12, br. 1, str. 1-6
p-ISSN1840-2445
e-ISSN1840-0132
URN:NBNurn:nbn:hr:239:215205
Datum objave publikacije2015
URL dokumentahttps://pdfs.semanticscholar.org/38e7/85aa5627f6160a5064b0beab4e04133bc13c.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2019-11-06 09:31:01