prikaz prve stranice dokumenta Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis
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Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis
International Journal of Environmental Research and Public Health, 14 (2017), 1; 1-13. https://doi.org/10.3390/ijerph14010109
Kizivat, Tomislav; Smolić, Martina; Marić, Ivana; Tolušić Levak, Maja; Smolić, Robert; Bilić Ćurčić, Ines; Kuna, Lucija; Mihaljević, Ivan; Včev, Aleksandar; Tucak-Zorić, Sandra

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Kizivat, T., Smolić, M., Marić, I., Tolušić Levak, M., Smolić, R., Bilić Ćurčić, I. ... Tucak Zorić, S. (2017). Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis. International Journal of Environmental Research and Public Health, 14. (1), 1-13. doi: 10.3390/ijerph14010109

Kizivat, Tomislav, et al. "Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis." International Journal of Environmental Research and Public Health, vol. 14, br. 1, 2017, str. 1-13. https://doi.org/10.3390/ijerph14010109

Kizivat, Tomislav, Martina Smolić, Ivana Marić, Maja Tolušić Levak, Robert Smolić, Ines Bilić Ćurčić, Lucija Kuna, Ivan Mihaljević, Aleksandar Včev i Sandra Tucak Zorić. "Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis." International Journal of Environmental Research and Public Health 14, br. 1 (2017): 1-13. https://doi.org/10.3390/ijerph14010109

Kizivat, T., et al. (2017) 'Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis', International Journal of Environmental Research and Public Health, 14(1), str. 1-13. doi: 10.3390/ijerph14010109

Kizivat T, Smolić M, Marić I, Tolušić Levak M, Smolić R, Bilić Ćurčić I, i sur.. Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis. International Journal of Environmental Research and Public Health [Internet]. 2017. [pristupljeno 17.04.2024.];14(1):1-13. doi: 10.3390/ijerph14010109

T. Kizivat, et al., "Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis", International Journal of Environmental Research and Public Health, vol. 14, br. 1, str. 1-13, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:713480. [Citirano: 17.04.2024.]

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Podaci o radu
Naslov (engleski)Antioxidant Pre-treatment Reduces the Toxic Effects of Oxalate on Renal Epithelial Cells in a Cell Culture Model of Urolithiasis
AutorTomislav Kizivat
MBZ: 302955
AutorMartina Smolić
MBZ: 292155
AutorIvana Marić
AutorMaja Tolušić Levak
MBZ: 338680
AutorRobert Smolić
MBZ: 292166
AutorInes Bilić Ćurčić
MBZ: 268184
AutorLucija Kuna
MBZ: 353546
AutorIvan Mihaljević
AutorAleksandar Včev
MBZ: 141721
AutorSandra Tucak-Zorić
MBZ: 320540
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
Urolithiasis is characterized by the formation and retention of solid crystals within the urinary tract. Kidney stones are mostly composed of calcium oxalate, which predominantly generates free radicals that are toxic to renal tubular cells. The aim of the study is to explore possible effects of antioxidant pre-treatment on inhibition of oxidative stress. Three cell lines were used as in vitro model of urolithiasis: MDCK I, MDCK II and LLC-PK1. Oxidative stress was induced by exposure of cells to sodium oxalate in concentration of 8 mM. In order to prevent oxidative stress, cells were pre-treated with three different concentrations of l-arginine and vitamin E. Oxidative stress was evaluated by determining the expression of superoxide dismutase (SOD), osteopontin (OPN), and by the concentration of glutathione (GSH). In all three cell lines, pre-treatment of antioxidants increased cell survival. Positive correlation of SOD and OPN expression as well as GSH concentration was observed in all groups of cells. Our results indicate that an antioxidant pre-treatment with l-arginine and vitamin E is able to hamper oxalate-induced oxidative stress in kidney epithelial cells and as such could play a role in prevention of urolithiasis
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Environmental Research and Public Health
Brojčani podacivol. 14, br. 1, str. 1-13
e-ISSN1660-4601
DOIhttps://doi.org/10.3390/ijerph14010109
URN:NBNurn:nbn:hr:239:713480
Datum objave publikacije2017
URL dokumentahttps://www.mdpi.com/1660-4601/14/1/109
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-10-29 09:17:18