prikaz prve stranice dokumenta Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy
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Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy
Kidney and Blood Pressure Research, 41 (2016), 6; 721-735. https://doi.org/10.1159/000450562
Mihalj, Martina; Tadžić, Refmir; Včev, Aleksandar; Ručević, Silvija; Drenjančević, Ines

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Mihalj, M., Tadžić, R., Včev, A., Ručević, S. i Drenjančević, I. (2016). Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy. Kidney and Blood Pressure Research, 41. (6), 721-735. doi: 10.1159/000450562

Mihalj, Martina, et al. "Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy." Kidney and Blood Pressure Research, vol. 41, br. 6, 2016, str. 721-735. https://doi.org/10.1159/000450562

Mihalj, Martina, Refmir Tadžić, Aleksandar Včev, Silvija Ručević i Ines Drenjančević. "Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy." Kidney and Blood Pressure Research 41, br. 6 (2016): 721-735. https://doi.org/10.1159/000450562

Mihalj, M., et al. (2016) 'Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy', Kidney and Blood Pressure Research, 41(6), str. 721-735. doi: 10.1159/000450562

Mihalj M, Tadžić R, Včev A, Ručević S, Drenjančević I. Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy. Kidney and Blood Pressure Research [Internet]. 2016. [pristupljeno 10.12.2024.];41(6):721-735. doi: 10.1159/000450562

M. Mihalj, R. Tadžić, A. Včev, S. Ručević i I. Drenjančević, "Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy", Kidney and Blood Pressure Research, vol. 41, br. 6, str. 721-735, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:280651. [Citirano: 10.12.2024.]

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Podaci o radu
Naslov (engleski)Blood Pressure Reduction is Associated with the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy
AutorMartina Mihalj
MBZ: 322792
AutorRefmir Tadžić
MBZ: 350034
AutorAleksandar Včev
MBZ: 141721
AutorSilvija Ručević
MBZ: 277480
AutorInes Drenjančević
MBZ: 209603
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
BACKGROUND/AIMS: Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodium dismutase activity. This study aimed to investigate the effects of antihypertensive therapy and also vitamin C/E supplementation on BP, oxidative stress and endothelial activation in patients with essential hypertension. METHODS: Newly discovered patients received ARB/olmesartan or the Ca2+-channel blocker (CCB)/amlodipine, and additionally vitamin C/E or placebo throughout weeks 9-16. ELISA was used to determine 8-iso-prostaglendin F2-alpha (8iPGF2α) and endothelial activation markers. RESULTS: In both groups BP was normalized during first 8 weeks of therapy. Vitamins C/E had no additional BP-lowering effect. The vitamins C/E supplementation was not effective in reducing absolute values of 8iPGF2α; however; the magnitude of 8iPGF2α reduction was significantly greater in patients taking vitamins C/E in the CCB group. Although plasma 8iPGF2α positively correlated to BP, a significant decrease occurred during an additional 8 weeks of treatment. There were no changes in endothelial activation markers related to the specific action of ARB or CCB. CONCLUSIONS: Present study suggests that observed oxidative stress is a consequence of hypertension. BP reduction is associated with the observed decrease in oxidative stress and changes in endothelial activation regardless of antihypertensive therapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaKidney and Blood Pressure Research
Brojčani podacivol. 41, br. 6, str. 721-735
p-ISSN1420-4096
e-ISSN1423-0143
DOIhttps://doi.org/10.1159/000450562
URN:NBNurn:nbn:hr:239:280651
Datum objave publikacije2016
URL dokumentahttps://www.karger.com/Article/FullText/450562
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2019-10-31 08:13:50