prikaz prve stranice dokumenta Differential Expression of TFF Genes and Proteins in Breast Tumors
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Differential Expression of TFF Genes and Proteins in Breast Tumors
Acta clinica Croatica, 57 (2018), 2; 264-277. https://doi.org/10.20471/acc.2018.57.02.06
Tolušić Levak, Maja; Mihalj, Martina; Koprivčić, Ivan; Lovrić, Ivana; Novak, Sanja; Bijelić, Nikola; Baus-Lončar, Mirela; Belovari, Tatjana; Kralik, Kristina; Pauzar, Biljana

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Tolušić Levak, M., Mihalj, M., Koprivčić, I., Lovrić, I., Novak, S., Bijelić, N. ... Pauzar, B. (2018). Differential Expression of TFF Genes and Proteins in Breast Tumors. Acta clinica Croatica, 57. (2), 264-277. doi: 10.20471/acc.2018.57.02.06

Tolušić Levak, Maja, et al. "Differential Expression of TFF Genes and Proteins in Breast Tumors." Acta clinica Croatica, vol. 57, br. 2, 2018, str. 264-277. https://doi.org/10.20471/acc.2018.57.02.06

Tolušić Levak, Maja, Martina Mihalj, Ivan Koprivčić, Ivana Lovrić, Sanja Novak, Nikola Bijelić, Mirela Baus Lončar, Tatjana Belovari, Kristina Kralik i Biljana Pauzar. "Differential Expression of TFF Genes and Proteins in Breast Tumors." Acta clinica Croatica 57, br. 2 (2018): 264-277. https://doi.org/10.20471/acc.2018.57.02.06

Tolušić Levak, M., et al. (2018) 'Differential Expression of TFF Genes and Proteins in Breast Tumors', Acta clinica Croatica, 57(2), str. 264-277. doi: 10.20471/acc.2018.57.02.06

Tolušić Levak M, Mihalj M, Koprivčić I, Lovrić I, Novak S, Bijelić N, i sur.. Differential Expression of TFF Genes and Proteins in Breast Tumors. Acta clinica Croatica [Internet]. 2018. [pristupljeno 17.11.2024.];57(2):264-277. doi: 10.20471/acc.2018.57.02.06

M. Tolušić Levak, et al., "Differential Expression of TFF Genes and Proteins in Breast Tumors", Acta clinica Croatica, vol. 57, br. 2, str. 264-277, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:128292. [Citirano: 17.11.2024.]

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Podaci o radu
Naslov (engleski)Differential Expression of TFF Genes and Proteins in Breast Tumors
AutorMaja Tolušić Levak
MBZ: 338680
AutorMartina Mihalj
MBZ: 322792
AutorIvan Koprivčić
MBZ: 311933
AutorIvana Lovrić
AutorSanja Novak
MBZ: 326355
AutorNikola Bijelić
MBZ: 313935
AutorMirela Baus-Lončar
MBZ: 222563
AutorTatjana Belovari
MBZ: 209063
AutorKristina Kralik
AutorBiljana Pauzar
MBZ: 209910
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
The objective of this study was to determine differential expression of TFF1, TFF2 and TFF3 genes and proteins in breast tumor subtypes. In addition, we investigated the correlation between TFF genes within tumor subgroups, and TFF genes with clinical and pathologic characteristics of the tumor. Study group included 122 patients with surgically removed breast tumors. Samples were investigated using qRT-PCR and immunohistochemistry. TFF1 and TFF3 genes and proteins were expressed in breast tumors, while the levels of TFF2 gene and protein expression were very low or undetectable. TFF1 was significantly more expressed in benign tumors, while TFF3 was more expressed in malignant tumors. Gene and protein expression of both TFF1 and TFF3 was greater in lymph node-negative tumors, hormone positive tumors, tumors with moderate levels of Ki67 expression, and in grade II tumors. A strong positive correlation was found between TFF1 and TFF3 genes, and the expression of both negatively correlated with Ki67 and the level of tumor histologic differentiation. Our results suggest that TFF1 and TFF3, but not TFF2, may have a role in breast tumor pathogenesis and could be used in the assessment of tumor differentiation and malignancy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa clinica Croatica
Brojčani podacivol. 57, br. 2, str. 264-277
p-ISSN0353-9466
e-ISSN1333-9451
DOIhttps://doi.org/10.20471/acc.2018.57.02.06
URN:NBNurn:nbn:hr:239:128292
Datum objave publikacije2018
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532012/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-SA 4.0)
Datum i vrijeme pohrane2020-01-21 12:24:18