prikaz prve stranice dokumenta Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin
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Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin
Molecules, 22 (2017), 7; 2-14. https://doi.org/10.3390/molecules22071153
Rimac, Hrvoje; Dufour, Claire; Debeljak, Željko; Zorc, Branka; Bojić, Mirza

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Rimac, H., Dufour, C., Debeljak, Ž., Zorc, B. i Bojić, M. (2017). Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin. Molecules, 22. (7), 2-14. doi: 10.3390/molecules22071153

Rimac, Hrvoje, et al. "Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin." Molecules, vol. 22, br. 7, 2017, str. 2-14. https://doi.org/10.3390/molecules22071153

Rimac, Hrvoje, Claire Dufour, Željko Debeljak, Branka Zorc i Mirza Bojić. "Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin." Molecules 22, br. 7 (2017): 2-14. https://doi.org/10.3390/molecules22071153

Rimac, H., et al. (2017) 'Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin', Molecules, 22(7), str. 2-14. doi: 10.3390/molecules22071153

Rimac H, Dufour C, Debeljak Ž, Zorc B, Bojić M. Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin. Molecules [Internet]. 2017. [pristupljeno 17.11.2024.];22(7):2-14. doi: 10.3390/molecules22071153

H. Rimac, C. Dufour, Ž. Debeljak, B. Zorc i M. Bojić, "Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin", Molecules, vol. 22, br. 7, str. 2-14, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:860737. [Citirano: 17.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:239:860737
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Podaci o radu
Naslov (engleski)Warfarin and Flavonoids do not Share the Same Binding Region in Binding to the IIA Subdomain of Human Serum Albumin
AutorHrvoje Rimac
MBZ: 335535
AutorClaire Dufour
AutorŽeljko Debeljak
MBZ: 296571
AutorBranka Zorc
MBZ: 80914
AutorMirza Bojić
MBZ: 298301
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Medicinska biokemija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Human serum albumin (HSA) binds a variety of xenobiotics, including flavonoids and warfarin. The binding of another ligand to the IIA binding site on HSA can cause warfarin displacement and potentially the elevation of its free concentration in blood. Studies dealing with flavonoid-induced warfarin displacement from HSA provided controversial results: estimated risk of displacement ranged from none to serious. To resolve these controversies, in vitro study of simultaneous binding of warfarin and eight different flavonoid aglycons and glycosides to HSA was carried out by fluorescence spectroscopy as well as molecular docking. Results show that warfarin and flavonoids do not share the same binding region in binding to HSA. Interactions were only observed at high warfarin concentrations not attainable under recommended dosing regimes. Docking experiments show that flavonoid aglycons and glycosides do not bind at warfarin high affinity sites, but rather to different regions within the IIA HSA subdomain. Thus, the risk of clinically significant warfarin-flavonoid interaction in binding to HSA should be regarded as negligible.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeStručni rad - Stručni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecules
Brojčani podacivol. 22, br. 7, str. 2-14
e-ISSN1420-3049
DOIhttps://doi.org/10.3390/molecules22071153
URN:NBNurn:nbn:hr:239:860737
Datum objave publikacije2017
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152318/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-05-04 09:40:40