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The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience
Medicinski glasnik, 16 (2019), 1; 53-59. https://doi.org/10.17392/994-19
Muller, Andrijana; Horvat, Vesna; Vulin, Martina; Mandić, Sanja; Šerić, Vatroslav; Vidosavljević, Domagoj

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Muller, A., Horvat, V., Vulin, M., Mandić, S., Šerić, V. i Vidosavljević, D. (2019). The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience. Medicinski glasnik, 16. (1), 53-59. doi: 10.17392/994-19

Muller, Andrijana, et al. "The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience." Medicinski glasnik, vol. 16, br. 1, 2019, str. 53-59. https://doi.org/10.17392/994-19

Muller, Andrijana, Vesna Horvat, Martina Vulin, Sanja Mandić, Vatroslav Šerić i Domagoj Vidosavljević. "The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience." Medicinski glasnik 16, br. 1 (2019): 53-59. https://doi.org/10.17392/994-19

Muller, A., et al. (2019) 'The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience', Medicinski glasnik, 16(1), str. 53-59. doi: 10.17392/994-19

Muller A, Horvat V, Vulin M, Mandić S, Šerić V, Vidosavljević D. The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience. Medicinski glasnik [Internet]. 2019. [pristupljeno 08.12.2024.];16(1):53-59. doi: 10.17392/994-19

A. Muller, V. Horvat, M. Vulin, S. Mandić, V. Šerić i D. Vidosavljević, "The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience", Medicinski glasnik, vol. 16, br. 1, str. 53-59, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:582124. [Citirano: 08.12.2024.]

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Naslov (engleski)The Soluble Fms-like Tyrosin Kinase-1 (sFLT-1) to Placental Growth Factor (PIGF) Ratio as a Possible Indicator for the Severity of Preeclampsia - Single Institution Experience
AutorAndrijana Muller
MBZ: 294701
AutorVesna Horvat
MBZ: 349024
AutorMartina Vulin
AutorSanja Mandić
MBZ: 349013
AutorVatroslav Šerić
MBZ: 193563
AutorDomagoj Vidosavljević
MBZ: 323012
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ginekologija i opstetricija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Farmacija
Medicinska biokemija
Sažetak (engleski)
Aim To investigate a potential of the clinical use of the soluble fms-like tyrosine kinase 1 (sFLT-1) to placental growth factor (PlGF) ratio from the perspective of a small hospital centre. Methods Maternal serum samples were analysed at 241/7-28 0/7, and 281/7-320/7 weeks of gestation. The level of sFLT-1 and PIGF was determined by immunoassay platform and used to calculate the sFLT-1/PIGF ratio in 35 pregnant women, and divided into subgroups according to preeclampsia occurrence at the time of delivery: preterm (≤37 weeks) or term (37-42 weeks'), and matched a control group. Results Patients in the preterm delivery group had a significantly higher incidence of intrauterine growth restriction, lower gestational age at the time of delivery, and lower infant birth weight compared to the other two groups. There was a negative correlation between the sFLT-1/PlGF ratio and GA and between the sFLT-1/ PlGF ratio and birth weight at the time of delivery. The value of the sFLT-1/PlGF ratio was significantly higher in the preterm delivery PE group. All the PE group pregnancies ended with caesarean delivery compared to 25% in the control group. However, none of the patients from the PE group had any of the possible complications of preeclampsia nor did they require additional therapy such as blood transfusion or additional non-standard hypertensive therapy. Conclusion The sFLT-1/PlGF ratio could be used as an indicator for the development and estimation of the severity of PE to provide objective evidence for the management of preeclampsia patients, and as a predictive marker of preeclampsia at low cost.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMedicinski glasnik
Brojčani podacivol. 16, br. 1, str. 53-59
p-ISSN1840-0132
e-ISSN1840-2445
DOIhttps://doi.org/10.17392/994-19
URN:NBNurn:nbn:hr:239:582124
Datum objave publikacije2019
URL dokumentahttp://ljkzedo.ba/mg30/19-Muller-994-A.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-SA 4.0)
Datum i vrijeme pohrane2020-05-15 09:35:28