prikaz prve stranice dokumenta Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population
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Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population
Collegium antropologicum, 38 (2014), 4; 393-400. urn:nbn:hr:239:181246
Horvat, Vesna; Mandić, Sanja; Marczi, Saška; Mrčela, Milanka; Galić, Josip

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Horvat, V., Mandić, S., Marczi, S., Mrčela, M. i Galić, J. (2014). Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population. Collegium antropologicum, 38. (4), 393-400. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:239:181246

Horvat, Vesna, et al. "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population." Collegium antropologicum, vol. 38, br. 4, 2014, str. 393-400. https://urn.nsk.hr/urn:nbn:hr:239:181246

Horvat, Vesna, Sanja Mandić, Saška Marczi, Milanka Mrčela i Josip Galić. "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population." Collegium antropologicum 38, br. 4 (2014): 393-400. https://urn.nsk.hr/urn:nbn:hr:239:181246

Horvat, V., et al. (2014) 'Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population', Collegium antropologicum, 38(4), str. 393-400. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:239:181246 (Datum pristupa: 08.12.2024.)

Horvat V, Mandić S, Marczi S, Mrčela M, Galić J. Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population. Collegium antropologicum [Internet]. 2014. [pristupljeno 08.12.2024.];38(4):393-400. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:181246

V. Horvat, S. Mandić, S. Marczi, M. Mrčela i J. Galić, "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population", Collegium antropologicum, vol. 38, br. 4, str. 393-400, 2014. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:181246. [Citirano: 08.12.2024.]

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Podaci o radu
Naslov (engleski)Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population
Naslov (hrvatski)Povezanost il-1b i il-10 polimorfizama s rizikom i progresijom raka prostate u populaciji istočne Hrvatske
AutorVesna Horvat
MBZ: 349024
AutorSanja Mandić
MBZ: 349013
AutorSaška Marczi
MBZ: 254853
AutorMilanka Mrčela
MBZ: 224701
AutorJosip Galić
Autorova ustanova(Klinički bolnički centar Osijek)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
Single nuclear polymorphisms (SNPs) in the promotor regions of cytokine genes included in angiogenesis may influence prostate cancer (PCa) development via regulation of the pathways of tumor angiogenesis. The aim of the present study was to investigate the association of IL-1β+3954 (rs1143634) and IL-10-1082 (rs1800896) polymorphisms with PCa risk and aggressiveness in eastern Croatian patients. One hundred twenty PCa patients and 120 benign prostatic hyperplasia (BPH) controls were genotyped using real-time PCR (LightCycler Instrument, Roche Diagnostics) and the melting curve analysis method. There was no significant difference in the frequency of genotypes for the two polymorphisms between PCa patients and controls (χ2=0.857, p=0.355 for IL-β1; χ2=0.026, p=0.872 for IL-10). Carriers of the IL-10-1082A>G variant were found to be associated with the Gleason score (GS)>7 (AA versus GA+GG, OR=3.47, 95% CI 1.11-10.88, p=0.033). There was no significant difference in the frequency of genotypes for the two polymorphisms and the presence of metastatic disease in PCa patients. These results suggest that tested SNPs associated with differential production of IL-1β and IL-10 are not risk factors for PCa and do not correlate with the presence of distant metastasis in eastern Croatians. We found that IL-10-1082 GA+/or GG carriers have a higher risk of developing PCa with GS>7 in eastern Croatians.
Sažetak (hrvatski)
Pojedinačni nuklearni polimorfi zmi (SNP) u promotorskim regijama gena citokina uključenih u angiogenezu, mogu utjecati na razvoj karcinoma prostate (PCa) regulacijom putova angiogeneze tumora. Cilj ove studije bio je istražiti povezanost IL-1b+3954 (rs1143634) i IL-10-1082 (rs1800896) polimorfi zama s rizikom i agresivnošću karcinoma prostate kod pacijenata iz istočne Hrvatske. 120 pacijenata s karcinomom prostate i 120 kontrola s benignom hiperplazijom prostate (BPH) genotipizirani su metodom lančane reakcije polimerazom u stvarnom vremenu (eng. real-time PCR) i analizom krivulje temperature taljenja pomoću tehnologije LightCycler (Roche Diagnostics). Nije bilo značajne razlike u učestalosti genotipova za dva polimorfi zma između PCa bolesnika i kontrola (c2=0,857, p=0,355 za IL-b1; c2=0,026, p=0,872 za IL-10). Utvrđena je povezanost nosioca IL-10-1082A>G varijante s GS>7 (AA u odnosu na GA+GG, OR=3,47; 95% CI 1.11 do 10,88, p=0,033). Nije bilo značajne razlike u učestalosti genotipova za dva polimorfi zma i prisutnosti metastatske bolesti u PCa bolesnika. Ovi rezultati sugeriraju da testirani SNP-ovi, povezani s različitom produkcijom IL-1b i IL-10, nisu čimbenici rizika za PCa i ne koreliraju s prisutnošću metastaza kod ispitanika u istočnoj Hrvatskoj. Otkrili smo da u istočnoj Hrvatskoj, nositelji IL-10-1082 GA +/ili GG genotipa imaju veći rizik razvoja PCa s GS>7.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 38, br. 4, str. 393-400
p-ISSN0350-6134
URN:NBNurn:nbn:hr:239:181246
Datum objave publikacije2014
URL dokumentahttps://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=245096
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2020-05-15 10:02:28