prikaz prve stranice dokumenta Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats
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Scientific paper - Original scientific paper
Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats
Canadian Journal of Physiology and Pharmacology, 68 (2017), 2; 265-272. urn:nbn:hr:239:062826
Vitaić, Sandra; Stupnišek, Mirjana; Drmić, Domagoj; Bauk, Lara; Kokot, Antonio; Kliček, Robert; Včev, Aleksandar; Luetić, Krešimir; Seiwerth, Sven; Sikirić, Predrag

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Vitaić, S., Stupnišek, M., Drmić, D., Bauk, L., Kokot, A., Kliček, R. ... Sikirić, P. (2017). Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats. Canadian Journal of Physiology and Pharmacology, 68. (2), 265-272. Retrieved from https://urn.nsk.hr/urn:nbn:hr:239:062826

Vitaić, Sandra, et al. "Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats." Canadian Journal of Physiology and Pharmacology, vol. 68, no. 2, 2017, pp. 265-272. https://urn.nsk.hr/urn:nbn:hr:239:062826

Vitaić, Sandra, Mirjana Stupnišek, Domagoj Drmić, Lara Bauk, Antonio Kokot, Robert Kliček, Aleksandar Včev, Krešimir Luetić, Sven Seiwerth and Predrag Sikirić. "Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats." Canadian Journal of Physiology and Pharmacology 68, no. 2 (2017): 265-272. https://urn.nsk.hr/urn:nbn:hr:239:062826

Vitaić, S., et al. (2017) 'Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats', Canadian Journal of Physiology and Pharmacology, 68(2), pp. 265-272. Available at: https://urn.nsk.hr/urn:nbn:hr:239:062826 (Accessed 29 October 2024)

Vitaić S, Stupnišek M, Drmić D, Bauk L, Kokot A, Kliček R, and sur.. Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats. Canadian Journal of Physiology and Pharmacology [Internet]. 2017 [cited 2024 October 29];68(2):265-272. Available at: https://urn.nsk.hr/urn:nbn:hr:239:062826

S. Vitaić, et al., "Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats", Canadian Journal of Physiology and Pharmacology, vol. 68, no. 2, pp. 265-272, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:062826. [Accessed: 29 October 2024]

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Metadata
Title (english)Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats
AuthorSandra Vitaić
AuthorMirjana Stupnišek
MBZ: 336891
AuthorDomagoj Drmić
AuthorLara Bauk
AuthorAntonio Kokot
MBZ: 322924
AuthorRobert Kliček
MBZ: 352126
AuthorAleksandar Včev
MBZ: 141721
AuthorKrešimir Luetić
MBZ: 350984
AuthorSven Seiwerth
MBZ: 149676
AuthorPredrag Sikirić
MBZ: 117454
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Veterinary Medicine
Basic and Preclinical Veterinary Sciences
Abstract (english)
The sphincters failure is a part of NSAIDs-toxicity that can be accordingly counteracted. We used a safe stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419), LD1 not achieved, since successful in inflammatory bowel disease trials, and counteracts esophagitis, sphincters failure, gastrointestinal ulcer and skin ulcer, external and internal fistulas in rats, and particularly counteracts all NSAIDs-lesions. We assessed lower esophageal sphincter and pyloric sphincter pressure (cmH2O) in rats treated with various NSAIDs regimens, at corresponding time points, known to produce stomach, small intestine lesions, hepatotoxicity and encephalopathy. Assessment was after diclofenac (12.5 mg/kg, 40 mg/kg intraperitoneal challenge), ibuprofen (400 mg/day/kg intraperitoneally for 4 weeks), paracetamol (5.0 g/kg intraperitoneal challenge), aspirin (400 mg/kg intraperitoneally or intragastrically), celecoxib (0.5 mg/kg, 1.0 mg/kg intraperitoneally). BPC 157 (10 μg/kg, 10 ng/kg) was given immediately after NSAIDs (intraperitoneally or intragastrically) or given in drinking water. Regularly, in all control NSAIDs fall of pressure occurred in both sphincters rapidly and then persisted. By contrast, in all NSAIDs-rats that received BPC 157, initial fall of pressure was minimized and pressure values restored to normal values. All tested NSAIDs decrease pressure in both sphincters, whilst BPC 157 counteracts their effects and restored both sphincters function.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCanadian Journal of Physiology and Pharmacology
Numberingvol. 68, no. 2, pp. 265-272
p-ISSN0008-4212
e-ISSN1205-7541
URN:NBNurn:nbn:hr:239:062826
Publication2017
Document URLhttps://pdfs.semanticscholar.org/0346/5dc129e85b834b60d7c235393eb28760b17d.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-11-05 12:21:36