prikaz prve stranice dokumenta Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats
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Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats
Canadian Journal of Physiology and Pharmacology, 68 (2017), 2; 265-272. urn:nbn:hr:239:062826
Vitaić, Sandra; Stupnišek, Mirjana; Drmić, Domagoj; Bauk, Lara; Kokot, Antonio; Kliček, Robert; Včev, Aleksandar; Luetić, Krešimir; Seiwerth, Sven; Sikirić, Predrag

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Vitaić, S., Stupnišek, M., Drmić, D., Bauk, L., Kokot, A., Kliček, R. ... Sikirić, P. (2017). Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats. Canadian Journal of Physiology and Pharmacology, 68. (2), 265-272. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:239:062826

Vitaić, Sandra, et al. "Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats." Canadian Journal of Physiology and Pharmacology, vol. 68, br. 2, 2017, str. 265-272. https://urn.nsk.hr/urn:nbn:hr:239:062826

Vitaić, Sandra, Mirjana Stupnišek, Domagoj Drmić, Lara Bauk, Antonio Kokot, Robert Kliček, Aleksandar Včev, Krešimir Luetić, Sven Seiwerth i Predrag Sikirić. "Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats." Canadian Journal of Physiology and Pharmacology 68, br. 2 (2017): 265-272. https://urn.nsk.hr/urn:nbn:hr:239:062826

Vitaić, S., et al. (2017) 'Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats', Canadian Journal of Physiology and Pharmacology, 68(2), str. 265-272. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:239:062826 (Datum pristupa: 16.12.2024.)

Vitaić S, Stupnišek M, Drmić D, Bauk L, Kokot A, Kliček R, i sur.. Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats. Canadian Journal of Physiology and Pharmacology [Internet]. 2017. [pristupljeno 16.12.2024.];68(2):265-272. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:062826

S. Vitaić, et al., "Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats", Canadian Journal of Physiology and Pharmacology, vol. 68, br. 2, str. 265-272, 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:062826. [Citirano: 16.12.2024.]

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Podaci o radu
Naslov (engleski)Nonsteroidal Anti-inflammatory Drugs-induced Failure of Lower Esophageal and Pyloric Sphincter and Counteraction of Sphincters Failure with Stable Gastric Pentadecapeptide BPC 157 in rats
AutorSandra Vitaić
AutorMirjana Stupnišek
MBZ: 336891
AutorDomagoj Drmić
AutorLara Bauk
AutorAntonio Kokot
MBZ: 322924
AutorRobert Kliček
MBZ: 352126
AutorAleksandar Včev
MBZ: 141721
AutorKrešimir Luetić
MBZ: 350984
AutorSven Seiwerth
MBZ: 149676
AutorPredrag Sikirić
MBZ: 117454
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Veterinarska medicina
Temeljne i pretkliničke veterinarske znanosti
Sažetak (engleski)
The sphincters failure is a part of NSAIDs-toxicity that can be accordingly counteracted. We used a safe stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419), LD1 not achieved, since successful in inflammatory bowel disease trials, and counteracts esophagitis, sphincters failure, gastrointestinal ulcer and skin ulcer, external and internal fistulas in rats, and particularly counteracts all NSAIDs-lesions. We assessed lower esophageal sphincter and pyloric sphincter pressure (cmH2O) in rats treated with various NSAIDs regimens, at corresponding time points, known to produce stomach, small intestine lesions, hepatotoxicity and encephalopathy. Assessment was after diclofenac (12.5 mg/kg, 40 mg/kg intraperitoneal challenge), ibuprofen (400 mg/day/kg intraperitoneally for 4 weeks), paracetamol (5.0 g/kg intraperitoneal challenge), aspirin (400 mg/kg intraperitoneally or intragastrically), celecoxib (0.5 mg/kg, 1.0 mg/kg intraperitoneally). BPC 157 (10 μg/kg, 10 ng/kg) was given immediately after NSAIDs (intraperitoneally or intragastrically) or given in drinking water. Regularly, in all control NSAIDs fall of pressure occurred in both sphincters rapidly and then persisted. By contrast, in all NSAIDs-rats that received BPC 157, initial fall of pressure was minimized and pressure values restored to normal values. All tested NSAIDs decrease pressure in both sphincters, whilst BPC 157 counteracts their effects and restored both sphincters function.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCanadian Journal of Physiology and Pharmacology
Brojčani podacivol. 68, br. 2, str. 265-272
p-ISSN0008-4212
e-ISSN1205-7541
URN:NBNurn:nbn:hr:239:062826
Datum objave publikacije2017
URL dokumentahttps://pdfs.semanticscholar.org/0346/5dc129e85b834b60d7c235393eb28760b17d.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2019-11-05 12:21:36