prikaz prve stranice dokumenta Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice
  Download
PDF 7.14 MB
Scientific paper - Original scientific paper
Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice
International Journal of Molecular Sciences, 20 (2019), 20; 1-25. https://doi.org/10.3390/ijms20205188
Kozina, Nataša; Mihaljević, Zrinka; Baus Lončar, Mirela; Mihalj, Martina; Mišir, Mihael; Dobrivojević Radmilović, Marina; Justić, Helena; Gajović, Srećko; Šešelja, Kate; Bazina, Iva; Horvatić, Anita; Matić, Anita; Bijelić, Nikola; Rođak, Edi; Jukić, Ivana; Drenjančević, Ines More authors...

Cite this document

Kozina, N., Mihaljević, Z., Baus Lončar, M., Mihalj, M., Mišir, M., Dobrivojević Radmilović, M. ... Drenjančević, I. (2019). Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice. International Journal of Molecular Sciences, 20. (20), 1-25. doi: 10.3390/ijms20205188

Kozina, Nataša, et al. "Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice." International Journal of Molecular Sciences, vol. 20, no. 20, 2019, pp. 1-25. https://doi.org/10.3390/ijms20205188

Kozina, Nataša, Zrinka Mihaljević, Mirela Baus Lončar, Martina Mihalj, Mihael Mišir, Marina Dobrivojević Radmilović, Helena Justić, et al. "Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice." International Journal of Molecular Sciences 20, no. 20 (2019): 1-25. https://doi.org/10.3390/ijms20205188

Kozina, N., et al. (2019) 'Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice', International Journal of Molecular Sciences, 20(20), pp. 1-25. doi: 10.3390/ijms20205188

Kozina N, Mihaljević Z, Baus Lončar M, Mihalj M, Mišir M, Dobrivojević Radmilović M, and sur.. Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice. International Journal of Molecular Sciences [Internet]. 2019 [cited 2024 December 07];20(20):1-25. doi: 10.3390/ijms20205188

N. Kozina, et al., "Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice", International Journal of Molecular Sciences, vol. 20, no. 20, pp. 1-25, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:276523. [Accessed: 07 December 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice
AuthorNataša Kozina
MBZ: 373585
AuthorZrinka Mihaljević
MBZ: 324952
AuthorMirela Baus Lončar
MBZ: 222563
AuthorMartina Mihalj
MBZ: 322792
AuthorMihael Mišir
MBZ: 357666
AuthorMarina Dobrivojević Radmilović
MBZ: 333511
AuthorHelena Justić
AuthorSrećko Gajović
MBZ: 162013
AuthorKate Šešelja
MBZ: 368290
AuthorIva Bazina
AuthorAnita Horvatić
MBZ: 316795
AuthorAnita Matić
MBZ: 326344
AuthorNikola Bijelić
MBZ: 313935
AuthorEdi Rođak
MBZ: 369662
AuthorIvana Jukić
AuthorInes Drenjančević
MBZ: 209603
Author's institutionRuđer Bošković Institute
Author's institution(Clinical hospital center Osijek)
Author's institutionUniversity of Zagreb
School of Medicine
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Food Chemistry and Biochemistry
Abstract (english)
High salt (HS) dietary intake leads to impaired vascular endothelium-dependent responses to various physiological stimuli, some of which are mediated by arachidonic acid (AA) metabolites. Transgenic Tff3-/- gene knockout mice (Tff3-/-/C57BL/6N) have changes in lipid metabolism which may affect vascular function and outcomes of stroke. We aimed to study the effects of one week of HS diet (4% NaCl) on vascular function and stroke induced by transient occlusion of middle cerebral artery in Tff3-/- and wild type (WT/C57BL/6N) mice. Flow-induced dilation (FID) of carotid artery was reduced in WT-HS mice, but not affected in Tff3-/--HS mice. Nitric oxide (NO) mediated FID. NO production was decreased with HS diet. On the contrary, acetylcholine-induced dilation was significantly decreased in Tff3-/- mice on both diets and WT-HS mice. HS intake and Tff3 gene depletion affected the structural components of the vessels. Proteomic analysis revealed a significant effect of Tff3 gene deficiency on HS diet-induced changes in neuronal structural proteins and acute innate immune response proteins' expression and Tff3 depletion, but HS diet did not increase the stroke volume, which is related to proteome modification and upregulation of genes involved mainly in cellular antioxidative defense. In conclusion, Tff3 depletion seems to partially impair vascular function and worsen the outcomes of stroke, which is moderately affected by HS diet.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 20, no. 20, pp. 1-25
p-ISSN1661-6596
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms20205188
URN:NBNurn:nbn:hr:239:276523
Publication2019
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829871/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-01-17 12:31:18