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Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice
International Journal of Molecular Sciences, 20 (2019), 20; 1-25. https://doi.org/10.3390/ijms20205188
Kozina, Nataša; Mihaljević, Zrinka; Baus Lončar, Mirela; Mihalj, Martina; Mišir, Mihael; Dobrivojević Radmilović, Marina; Justić, Helena; Gajović, Srećko; Šešelja, Kate; Bazina, Iva; Horvatić, Anita; Matić, Anita; Bijelić, Nikola; Rođak, Edi; Jukić, Ivana; Drenjančević, Ines Više autora...

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Kozina, N., Mihaljević, Z., Baus Lončar, M., Mihalj, M., Mišir, M., Dobrivojević Radmilović, M. ... Drenjančević, I. (2019). Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice. International Journal of Molecular Sciences, 20. (20), 1-25. doi: 10.3390/ijms20205188

Kozina, Nataša, et al. "Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice." International Journal of Molecular Sciences, vol. 20, br. 20, 2019, str. 1-25. https://doi.org/10.3390/ijms20205188

Kozina, Nataša, Zrinka Mihaljević, Mirela Baus Lončar, Martina Mihalj, Mihael Mišir, Marina Dobrivojević Radmilović, Helena Justić, et al. "Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice." International Journal of Molecular Sciences 20, br. 20 (2019): 1-25. https://doi.org/10.3390/ijms20205188

Kozina, N., et al. (2019) 'Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice', International Journal of Molecular Sciences, 20(20), str. 1-25. doi: 10.3390/ijms20205188

Kozina N, Mihaljević Z, Baus Lončar M, Mihalj M, Mišir M, Dobrivojević Radmilović M, i sur.. Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice. International Journal of Molecular Sciences [Internet]. 2019. [pristupljeno 10.12.2024.];20(20):1-25. doi: 10.3390/ijms20205188

N. Kozina, et al., "Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice", International Journal of Molecular Sciences, vol. 20, br. 20, str. 1-25, 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:276523. [Citirano: 10.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:239:276523
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Podaci o radu
Naslov (engleski)Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3-/-/C57BL/6N Knockout and WT (C57BL/6N) Control Mice
AutorNataša Kozina
MBZ: 373585
AutorZrinka Mihaljević
MBZ: 324952
AutorMirela Baus Lončar
MBZ: 222563
AutorMartina Mihalj
MBZ: 322792
AutorMihael Mišir
MBZ: 357666
AutorMarina Dobrivojević Radmilović
MBZ: 333511
AutorHelena Justić
AutorSrećko Gajović
MBZ: 162013
AutorKate Šešelja
MBZ: 368290
AutorIva Bazina
AutorAnita Horvatić
MBZ: 316795
AutorAnita Matić
MBZ: 326344
AutorNikola Bijelić
MBZ: 313935
AutorEdi Rođak
MBZ: 369662
AutorIvana Jukić
AutorInes Drenjančević
MBZ: 209603
Autorova ustanovaInstitut Ruđer Bošković
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Nutricionizam
Kemija i biokemija hrane
Sažetak (engleski)
High salt (HS) dietary intake leads to impaired vascular endothelium-dependent responses to various physiological stimuli, some of which are mediated by arachidonic acid (AA) metabolites. Transgenic Tff3-/- gene knockout mice (Tff3-/-/C57BL/6N) have changes in lipid metabolism which may affect vascular function and outcomes of stroke. We aimed to study the effects of one week of HS diet (4% NaCl) on vascular function and stroke induced by transient occlusion of middle cerebral artery in Tff3-/- and wild type (WT/C57BL/6N) mice. Flow-induced dilation (FID) of carotid artery was reduced in WT-HS mice, but not affected in Tff3-/--HS mice. Nitric oxide (NO) mediated FID. NO production was decreased with HS diet. On the contrary, acetylcholine-induced dilation was significantly decreased in Tff3-/- mice on both diets and WT-HS mice. HS intake and Tff3 gene depletion affected the structural components of the vessels. Proteomic analysis revealed a significant effect of Tff3 gene deficiency on HS diet-induced changes in neuronal structural proteins and acute innate immune response proteins' expression and Tff3 depletion, but HS diet did not increase the stroke volume, which is related to proteome modification and upregulation of genes involved mainly in cellular antioxidative defense. In conclusion, Tff3 depletion seems to partially impair vascular function and worsen the outcomes of stroke, which is moderately affected by HS diet.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 20, br. 20, str. 1-25
p-ISSN1661-6596
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms20205188
URN:NBNurn:nbn:hr:239:276523
Datum objave publikacije2019
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829871/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-01-17 12:31:18