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Scientific paper - Review paper
The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme
Molecules, 23 (2018), 10; 1-12. https://doi.org/10.3390/molecules23102553
Mustapić Šarić, Darija; Debeljak, Željko; Maleš, Željan; Bojić, Mirza

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Mustapić Šarić, D., Debeljak, Ž., Maleš, Ž. & Bojić, M. (2018). The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. Molecules, 23. (10), 1-12. doi: 10.3390/molecules23102553

Mustapić Šarić, Darija, et al. "The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme." Molecules, vol. 23, no. 10, 2018, pp. 1-12. https://doi.org/10.3390/molecules23102553

Mustapić Šarić, Darija, Željko Debeljak, Željan Maleš and Mirza Bojić. "The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme." Molecules 23, no. 10 (2018): 1-12. https://doi.org/10.3390/molecules23102553

Mustapić Šarić, D., et al. (2018) 'The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme', Molecules, 23(10), pp. 1-12. doi: 10.3390/molecules23102553

Mustapić Šarić D, Debeljak Ž, Maleš Ž, Bojić M. The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. Molecules [Internet]. 2018 [cited 2024 December 09];23(10):1-12. doi: 10.3390/molecules23102553

D. Mustapić Šarić, Ž. Debeljak, Ž. Maleš and M. Bojić, "The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme", Molecules, vol. 23, no. 10, pp. 1-12, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:527001. [Accessed: 09 December 2024]

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Metadata
Title (english)The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme
AuthorDarija Mustapić Šarić
AuthorŽeljko Debeljak
MBZ: 296571
AuthorŽeljan Maleš
MBZ: 142654
AuthorMirza Bojić
MBZ: 298301
Author's institution(Clinical hospital center Osijek)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
Author's institutionUniversity of Zagreb
Faculty of Science
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Biology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Abstract (english)
Flavonoids are natural compounds that have been extensively studied due to their positive effects on human health. There are over 4000 flavonoids found in higher plants and their beneficial effects have been shown in vitro as well as in vivo. However, data on their pharmacokinetics and influence on metabolic enzymes is scarce. The aim of this study was to focus on possible interactions between the 30 most commonly encountered flavonoid aglycones on the metabolic activity of CYP3A4 enzyme. 6β-hydroxylation of testosterone was used as marker reaction of CYP3A4 activity. Generated product was determined by HPLC coupled with diode array detector. Metabolism and time dependence, as well as direct inhibition, were tested to determine if inhibition was reversible and/or irreversible. Out of the 30 flavonoids tested, 7 significantly inhibited CYP3A4, most prominent being acacetin that inhibited 95% of enzyme activity at 1 µM concentration. Apigenin showed reversible inhibition, acacetin, and chrysin showed combined irreversible and reversible inhibition while chrysin dimethylether, isorhamnetin, pinocembrin, and tangeretin showed pure irreversible inhibition. These results alert on possible flavonoid–drug interactions on the level of CYP3A4.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMolecules
Numberingvol. 23, no. 10, pp. 1-12
e-ISSN1420-3049
DOIhttps://doi.org/10.3390/molecules23102553
URN:NBNurn:nbn:hr:239:527001
Publication2018
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222669/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-04-29 09:56:45