prikaz prve stranice dokumenta The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme
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The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme
Molecules, 23 (2018), 10; 1-12. https://doi.org/10.3390/molecules23102553
Mustapić Šarić, Darija; Debeljak, Željko; Maleš, Željan; Bojić, Mirza

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Mustapić Šarić, D., Debeljak, Ž., Maleš, Ž. i Bojić, M. (2018). The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. Molecules, 23. (10), 1-12. doi: 10.3390/molecules23102553

Mustapić Šarić, Darija, et al. "The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme." Molecules, vol. 23, br. 10, 2018, str. 1-12. https://doi.org/10.3390/molecules23102553

Mustapić Šarić, Darija, Željko Debeljak, Željan Maleš i Mirza Bojić. "The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme." Molecules 23, br. 10 (2018): 1-12. https://doi.org/10.3390/molecules23102553

Mustapić Šarić, D., et al. (2018) 'The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme', Molecules, 23(10), str. 1-12. doi: 10.3390/molecules23102553

Mustapić Šarić D, Debeljak Ž, Maleš Ž, Bojić M. The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme. Molecules [Internet]. 2018. [pristupljeno 10.12.2024.];23(10):1-12. doi: 10.3390/molecules23102553

D. Mustapić Šarić, Ž. Debeljak, Ž. Maleš i M. Bojić, "The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme", Molecules, vol. 23, br. 10, str. 1-12, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:527001. [Citirano: 10.12.2024.]

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Podaci o radu
Naslov (engleski)The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme
AutorDarija Mustapić Šarić
AutorŽeljko Debeljak
MBZ: 296571
AutorŽeljan Maleš
MBZ: 142654
AutorMirza Bojić
MBZ: 298301
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Autorova ustanovaSveučilište u Zagrebu
Farmaceutsko-biokemijski fakultet
Autorova ustanovaSveučilište u Zagrebu
Prirodoslovno-matematički fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOTEHNIČKE ZNANOSTI
Biotehnologija
Biologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička biokemija
Sažetak (engleski)
Flavonoids are natural compounds that have been extensively studied due to their positive effects on human health. There are over 4000 flavonoids found in higher plants and their beneficial effects have been shown in vitro as well as in vivo. However, data on their pharmacokinetics and influence on metabolic enzymes is scarce. The aim of this study was to focus on possible interactions between the 30 most commonly encountered flavonoid aglycones on the metabolic activity of CYP3A4 enzyme. 6β-hydroxylation of testosterone was used as marker reaction of CYP3A4 activity. Generated product was determined by HPLC coupled with diode array detector. Metabolism and time dependence, as well as direct inhibition, were tested to determine if inhibition was reversible and/or irreversible. Out of the 30 flavonoids tested, 7 significantly inhibited CYP3A4, most prominent being acacetin that inhibited 95% of enzyme activity at 1 µM concentration. Apigenin showed reversible inhibition, acacetin, and chrysin showed combined irreversible and reversible inhibition while chrysin dimethylether, isorhamnetin, pinocembrin, and tangeretin showed pure irreversible inhibition. These results alert on possible flavonoid–drug interactions on the level of CYP3A4.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaMolecules
Brojčani podacivol. 23, br. 10, str. 1-12
e-ISSN1420-3049
DOIhttps://doi.org/10.3390/molecules23102553
URN:NBNurn:nbn:hr:239:527001
Datum objave publikacije2018
URL dokumentahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222669/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2020-04-29 09:56:45