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Scientific paper - Original scientific paper
In Vitro Effect of Subminimal Inhibitory Concentrations of Antibiotics on the Biofilm Formation Ability of Acinetobacter Baumannii Clinical Isolates
Journal of Chemotherapy, 30 (2018), 1; 16-24. https://doi.org/10.1080/1120009X.2017.1378835
Bogdan, Maja; Drenjančević, Domagoj; Haršanji Drenjančević, Ivana; Bedenić, Branka; Zujić Atalić, Vlasta; Talapko, Jasminka; Vuković, Dubravka

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Bogdan, M., Drenjančević, D., Haršanji Drenjančević, I., Bedenić, B., Zujić Atalić, V., Talapko, J. & Vuković, D. (2018). In Vitro Effect of Subminimal Inhibitory Concentrations of Antibiotics on the Biofilm Formation Ability of Acinetobacter Baumannii Clinical Isolates. Journal of Chemotherapy, 30. (1), 16-24. doi: 10.1080/1120009X.2017.1378835

Bogdan, Maja, et al. "In Vitro Effect of Subminimal Inhibitory Concentrations of Antibiotics on the Biofilm Formation Ability of Acinetobacter Baumannii Clinical Isolates." Journal of Chemotherapy, vol. 30, no. 1, 2018, pp. 16-24. https://doi.org/10.1080/1120009X.2017.1378835

Bogdan, Maja, Domagoj Drenjančević, Ivana Haršanji Drenjančević, Branka Bedenić, Vlasta Zujić Atalić, Jasminka Talapko and Dubravka Vuković. "In Vitro Effect of Subminimal Inhibitory Concentrations of Antibiotics on the Biofilm Formation Ability of Acinetobacter Baumannii Clinical Isolates." Journal of Chemotherapy 30, no. 1 (2018): 16-24. https://doi.org/10.1080/1120009X.2017.1378835

Bogdan, M., et al. (2018) 'In Vitro Effect of Subminimal Inhibitory Concentrations of Antibiotics on the Biofilm Formation Ability of Acinetobacter Baumannii Clinical Isolates', Journal of Chemotherapy, 30(1), pp. 16-24. doi: 10.1080/1120009X.2017.1378835

Bogdan M, Drenjančević D, Haršanji Drenjančević I, Bedenić B, Zujić Atalić V, Talapko J, and sur.. In Vitro Effect of Subminimal Inhibitory Concentrations of Antibiotics on the Biofilm Formation Ability of Acinetobacter Baumannii Clinical Isolates. Journal of Chemotherapy [Internet]. 2018 [cited 2024 December 07];30(1):16-24. doi: 10.1080/1120009X.2017.1378835

M. Bogdan, et al., "In Vitro Effect of Subminimal Inhibitory Concentrations of Antibiotics on the Biofilm Formation Ability of Acinetobacter Baumannii Clinical Isolates", Journal of Chemotherapy, vol. 30, no. 1, pp. 16-24, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:239:928136. [Accessed: 07 December 2024]

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Metadata
Title (english)In Vitro Effect of Subminimal Inhibitory Concentrations of Antibiotics on the Biofilm Formation Ability of Acinetobacter Baumannii Clinical Isolates
AuthorMaja Bogdan
MBZ: 364346
AuthorDomagoj Drenjančević
MBZ: 297300
AuthorIvana Haršanji Drenjančević
MBZ: 363764
AuthorBranka Bedenić
MBZ: 178926
AuthorVlasta Zujić Atalić
MBZ: 375251
AuthorJasminka Talapko
MBZ: 377874
AuthorDubravka Vuković
Author's institution(Clinical hospital center Osijek)
Author's institutionUniversity of Zagreb
School of Medicine
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
(Department of Microbiology, Parasitology and Clinical Laboratory Diagnostics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Infectology
Abstract (english)
The ability of A cinetobacter baumannii strains to form biofilm is one of the most important virulence factor which enables bacterial survival in a harsh environment and decreases antibiotic concentration as well. Subminimal inhibitory concentrations (subMICs) of antibiotics may change bacterial ultrastructure or have an influence on some different molecular mechanisms resulting in morphological or physiological changes in bacteria itself. The aim of this study was to determine effects of 1/2, 1/4, 1/8 and 1/16 minimal inhibitory concentrationsof imipenem, ampicillin-sulbactam, azithromycin, rifampicin and colistin on biofilm formation ability of 22 biofilm non-producing and 46 biofilm producing A. baumannii strains (30 weak producing strains and 16 moderate producing strains). Results of this study indicate that 1/2-1/16 MICs of imipenem, azithromycin, and rifampicin can reduce bacterial biofilm formation ability in moderate producing strains (p < 0.05), whereas 1/16 MIC of imipenem and 1/4-1/8 MICs of rifampicin reduce the biofilm formation in weak producing strains (p < 0.05). Statisticaly significant effect was detected among biofilm non-producing strains after their exposure to 1/16 MIC of azithromycin (p = 0.039). SubMICs of ampicillin-sulbactam and colistin did not have any significant effect on biofilm formation among tested A. baumannii strains.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Chemotherapy
Numberingvol. 30, no. 1, pp. 16-24
p-ISSN1120-009X
e-ISSN1973-9478
DOIhttps://doi.org/10.1080/1120009X.2017.1378835
URN:NBNurn:nbn:hr:239:928136
Publication2018
Document URLhttps://www.tandfonline.com/doi/full/10.1080/1120009X.2017.1378835?scroll=top&needAccess=true
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2020-01-31 08:10:56