prikaz prve stranice dokumenta Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population
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Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population
Clinical Rheumatology, 34 (2015), 12; 2079-2086. https://doi.org/10.1007/s10067-015-2952-8
Perica, Marija; Vidović, Mandica; Lamot, Lovro; Tambić Bukovac, Lana; Kapitanović, Sanja; Perić, Magdalena; Barbić, Jerko; Harjaček, Miroslav

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Perica, M., Vidović, M., Lamot, L., Tambić Bukovac, L., Kapitanović, S., Perić, M. ... Harjaček, M. (2015). Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population. Clinical Rheumatology, 34. (12), 2079-2086. doi: 10.1007/s10067-015-2952-8

Perica, Marija, et al. "Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population." Clinical Rheumatology, vol. 34, br. 12, 2015, str. 2079-2086. https://doi.org/10.1007/s10067-015-2952-8

Perica, Marija, Mandica Vidović, Lovro Lamot, Lana Tambić Bukovac, Sanja Kapitanović, Magdalena Perić, Jerko Barbić i Miroslav Harjaček. "Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population." Clinical Rheumatology 34, br. 12 (2015): 2079-2086. https://doi.org/10.1007/s10067-015-2952-8

Perica, M., et al. (2015) 'Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population', Clinical Rheumatology, 34(12), str. 2079-2086. doi: 10.1007/s10067-015-2952-8

Perica M, Vidović M, Lamot L, Tambić Bukovac L, Kapitanović S, Perić M, i sur.. Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population. Clinical Rheumatology [Internet]. 2015. [pristupljeno 17.11.2024.];34(12):2079-2086. doi: 10.1007/s10067-015-2952-8

M. Perica, et al., "Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population", Clinical Rheumatology, vol. 34, br. 12, str. 2079-2086, 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:239:153096. [Citirano: 17.11.2024.]

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Podaci o radu
Naslov (engleski)Single Nucleotide Polymorphism of Toll-like Receptor 4 (TLR4) is Associated with Juvenile Spondyloarthritis in Croatian Population
AutorMarija Perica
AutorMandica Vidović
AutorLovro Lamot
MBZ: 301805
AutorLana Tambić Bukovac
MBZ: 192211
AutorSanja Kapitanović
MBZ: 200570
AutorMagdalena Perić
MBZ: 339363
AutorJerko Barbić
MBZ: 258420
AutorMiroslav Harjaček
MBZ: 240313
Autorova ustanova(Klinički bolnički centar Osijek)
Autorova ustanovaSveučilište Josipa Jurja Strossmayera u Osijeku
Medicinski fakultet Osijek
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Genetika, genomika i proteomika čovjeka
Znanstveno / umjetničko
područje, polje i grana		DRUŠTVENE ZNANOSTI
Demografija
Opća demografija
Sažetak (engleski)
Single nucleotide polymorphisms (SNP) of toll-like and NOD-like receptors have been associated with altered receptor activity and modified production of proinflammatory cytokines leading to a number of diseases. Our aim was to determine whether SNP of TLR2 (Arg753Gln), TLR4 (Asp299Gly, Thr399Ile), and NLRP3 (Q705K) influence susceptibility to juvenile spondyloarthrtis (jSpA) and juvenile idiopathic arthritis (JIA). After the DNA extraction, 26 patients with jSpA, 11 with oligoarticular, polyarticular, or systemic JIA, and 40 healthy controls were genotyped for Arg753Gln, Asp299Gly, Thr399Ile, and Q705K SNP using real-time PCR-SNP analysis. Statistically significant difference in genotype frequency for Thr399Ile SNP of TLR4 was observed in the jSpA (χ2 = 6.705, p = 0.035) and not in the JIA group (χ2 = 3005, p = 0.223). Regarding Asp299Gly SNP, no significant difference in genotype frequency was found; however, allele frequency was significant in both jSpA and JIA patients. No significant difference in genotype or allele frequency was observed for Arg735Gln and Q705K SNP. The399Ile polymorphism of TLR4 may be responsible for altered immune response to microbial infection in variant carriers and represent a mechanism of triggering overproduction of proinflammatory cytokines and long-term inflammation in jSpA. SNP of TLR2, NLRP3, and TLR4 (Asp299Gly) were not associated with jSpA or JIA.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical Rheumatology
Brojčani podacivol. 34, br. 12, str. 2079-2086
p-ISSN0770-3198
e-ISSN1434-9949
DOIhttps://doi.org/10.1007/s10067-015-2952-8
URN:NBNurn:nbn:hr:239:153096
Datum objave publikacije2015
URL dokumentahttps://link.springer.com/article/10.1007/s10067-015-3083-y
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-10-31 10:45:24